Evaluation of Adenosine deaminase, Serum C-reactive protein and alkaline phosphatase activity in Rheumatoid Arthritis patients in Shivamogga district, South India
Journal Title: International Journal of Clinical Biochemistry and Research - Year 2018, Vol 5, Issue 1
Abstract
Introduction & Objectives: Rheumatoid arthritis (RA) is a prototypical inflammatory joint disease. The degree of inflammation is reflected in the extent of joint damage, which further has influence on the quality of life of patients with RA. Serum adenosine deaminase (ADA) has been previously proposed to predict disease activity in patients with RA. The aim of this study was to investigate the level of serum ADA, CRP & ALP in Rheumatoid arthritis patients and compare it with healthy subjects. Materials and Methods: Fifty four RA patients and fifty four age matched healthy controls between 35-65 years were included in the study. ADA &ALP activity and CRP levels in serum were measured in all the subjects and correlated. Results: Serum ADA level was found significantly higher among RA subjects with respect to controls (31.37±4.16 versus 11.19±1.802 U/L; P < 0.0001). Serum ALP levels were also increased in RA cases as compared to controls and were statistically significant (145.17±15.86 versus 83.19±17.55 U/L; P < 0.0001). Serum CRP levels were also increased among RA subjects when compared to controls (2.60±1.16 versus 0.283±0.1161). Conclusion: ADA assay can be a reliable, sensitive and specific test. CRP is an important inflammatory marker for rapid diagnosis of rheumatoid arthritis. Increase in ALP in RA patients when compared to healthy controls suggests the role of serum ALP as a marker of disease activity in RA. However, larger and well controlled studies are needed to establish its role as inflammatory marker.
Authors and Affiliations
Sridevi V. , Dr. Chandrakanth, Vinit Anand
Keywords
Related Articles
- EP ID EP472138
- DOI 10.18231/2394-6377.2018.0028
- Views 70
- Downloads 0
A study of preanalytical errors in a hospital based clinical biochemistry laboratory and recommendation of required corrective measures
Background & Objective: The errors associated with the total testing process in laboratory, affecting clinical decision making, may occur at the pre-analytical, analytical and post-analytical phase. This study is aimed a...
Study of oxidative stress and endothelial dysfunction in paediatric obesity
Introduction: Obesity is associated with complications like Diabetes, Asthma, Hypertension and cardiovascular risks which are to be managed of health care worldwide. Increased BMI during childhood and adolescence may lea...
The synergistic role of CKMB mass and high sensitivity Troponin T in the diagnosis of Acute Coronary Syndrome
Aim: To determine the synergistic role of CKMB mass (CKMBM) and high sensitivity Troponin T (hs-cTnT) in the diagnosis of Acute Coronary Syndrome (ACS). Study Design: This was a cross-sectional study comprising of 140 in...
Biochemical Profile of women with pregnancy induced hypertension
Background: Hypertensive disorders complicating pregnancy are common and form one of the deadly triad, along with hemorrhage and infection. Pre-eclampsia is a syndrome of generalized endothelial dysfunction initiated by...
Role of biochemical markers in type 2 diabetic patients of cataract and retinopathy attending Index Medical College, Hospital and Research Centre, Indore (M.P)
Introduction: Aim of the study was to identify the role of selective serum lipids and serum creatinine in the development of type 2 DM microvascular complications like cataract and retinopathy which are potential cause o...