Evaluation of analgesic activity of ethanolic extract of alpinia galanga rhizomes in experimental animal models
Journal Title: Indian Journal of Pharmacy and Pharmacology - Year 2019, Vol 5, Issue 4
Abstract
Introduction Alpinia galanga Linn is a widely used medicinal plant It is also known as Greater Galangal and belongs to family Zingiberaceae The plant is a perennial rhizomatous herb and has been claimed to possess analgesic activity apart from many medicinal propertiesObjectives The aim of the present study was to evaluate the analgesic activity of ethanolic extract of alpinia galanga rhizomes EEAGR in experimental animalsMethods Acute toxicity test was done following the Organization of Economic Cooperation and Development guidelines100 mgkg 200 mgkg and 400 mgkg body weight bw of ethanolic extract of alpinia galanga rhizomes was given orally to experimental animals EEAGR was evaluated for central analgesic activity by using the tail flick method and peripheral analgesic activity by using the acetic acid induced writhing test using aspirin 300 mgkg bw and 100 mgkg bw orally as the standard drug respectivelyResults EEAGR at 400mgkg produced highly significant and greater analgesic activity than Aspirin standard drug in tail flick method EEAGR at dose 400mgkg has shown comparable reduction in mean total number of writhings which is equivalent to that of Aspirin standard drug in writhing testConclusion EEAGR has significant central and peripheral analgesic activityKeywords Alpinia galanga Analgesic Pain Tail flick Writhing
Authors and Affiliations
Dasari Sriraj, Mohd. Abdul Rauf
Keywords
Related Articles
- EP ID EP478566
- DOI 10.18231/2393-9087.2018.0034
- Views 87
- Downloads 0
Study of serum glucose and cholesterol level in schizophrenic patient’s before and after treatment of olanzapine, risperidone and haloperidol
Objectives To evaluate the potential association between antipsychotics Olanzapine Risperidone and Haloperidol serum glucose level and serum cholesterol level in schizophrenic patientsIntroduction Schizophrenia is quite...
Second year undergraduate medical student’s perceptions, their feedback regarding teaching methodologies and task based learning of pharmacology at Gulbarga Institute of Medical Sciences, Kalaburagi
Introduction Pharmacology like any other branch of medicine is progressing by leaps and bounds Consequently reforms in undergraduate teaching are the need of the hourObjectives To determine the medical studentsrsquo perc...
Cardioprotective and antihyperglycemic activity of vildagliptin in presence of nifedipine on adrenaline induced hyperglycemic rat
Generally there is higher prevalence of co-morbidity of diabetes and hypertension. Mortality increases more than 7 times when patient is having diabetes along with hypertension. In India 6.4% to 55% prevalence of hyperte...
An observational study to analyse the dose appropriateness of drugs prescribed in intensive care units of pediatric department
Introduction Pediatric age group comprises about 40 of total population of India Many medications are available to children and the safety of paediatric medications is an important public health issue The challenge all t...
Drug utilization pattern of acute poisoning admissions in medicine intensive care unit
Introduction Acute poisoning is a very common life threatening crisis and leads to serious conditions and even death of patients Poisoning may be due to self consumption or accidental of various chemical compounds medic...