Evaluation of analgesic activity of ethanolic extract of alpinia galanga rhizomes in experimental animal models
Journal Title: Indian Journal of Pharmacy and Pharmacology - Year 2019, Vol 5, Issue 4
Abstract
Introduction Alpinia galanga Linn is a widely used medicinal plant It is also known as Greater Galangal and belongs to family Zingiberaceae The plant is a perennial rhizomatous herb and has been claimed to possess analgesic activity apart from many medicinal propertiesObjectives The aim of the present study was to evaluate the analgesic activity of ethanolic extract of alpinia galanga rhizomes EEAGR in experimental animalsMethods Acute toxicity test was done following the Organization of Economic Cooperation and Development guidelines100 mgkg 200 mgkg and 400 mgkg body weight bw of ethanolic extract of alpinia galanga rhizomes was given orally to experimental animals EEAGR was evaluated for central analgesic activity by using the tail flick method and peripheral analgesic activity by using the acetic acid induced writhing test using aspirin 300 mgkg bw and 100 mgkg bw orally as the standard drug respectivelyResults EEAGR at 400mgkg produced highly significant and greater analgesic activity than Aspirin standard drug in tail flick method EEAGR at dose 400mgkg has shown comparable reduction in mean total number of writhings which is equivalent to that of Aspirin standard drug in writhing testConclusion EEAGR has significant central and peripheral analgesic activityKeywords Alpinia galanga Analgesic Pain Tail flick Writhing
Authors and Affiliations
Dasari Sriraj, Mohd. Abdul Rauf
Keywords
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