EVALUATION OF ANDROGRAPHIS PANICULATA (BURMF) WALL EX NEES, LEAF EXTRACTS AND ANDROGRAPHOLIDE ON GASTROINTESTINAL PATHOGENS
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2013, Vol 4, Issue 5
Abstract
Andrographis paniculata (BurmF) Wall Ex Nees called as Kalmegh or "King of Bitters is used in southeast Asia for treating several ailments. The aim of this study was to determine the antibacterial activity of Andrographis paniculata leaf extracts. The agar diffusion and micro-dilution methods were used to determine the antibacterial activity of the Petroleum ether and chloroform extracts. Chloroform and petroleum ether extracts inhibited Shigella, Proteus vulgaris, Klebsiella pneumonia and Salmonella paratyphi A at concentration of 10 and 1mg/ml respectively. The antibacterial property exhibited by the extracts were due to the presence of Andrographolide which was confirmed by HPLC analysis. Standard Andrographolide inhibited all bacterium except E.coli which indicates that it is a broad spectrum antibacterial compound. Although Andrographolide was effective against various gastrointestinal pathogens it does not have any harmful effect on the native flora.
Authors and Affiliations
R. Anitha , D. Raynukaa
Keywords
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