DEVELOPMENT AND VALIDATION OF A UV SPECTROPHOTOMETRIC METHOD FOR THE SIMULTANEOUS DETERMINATION OF NIFEDIPINE AND ATENOLOL IN COMBINED DOSAGE FORM
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2012, Vol 3, Issue 4
Abstract
Simultaneous estimation and validation of developed method of Nifedipine (NIF) and Atenolol (ATN) in combined dosage form as well as in laboratory mixture is studied under this paper. Nifedipine and Atenolol are used in combined dosage form for Cardiovascular System Diseases. The compound was identified by taking the IR spectra. The method is applied for laboratory mixture and marketed tablet. The developed method was validated as per ICH guidelines using the parameter such as accuracy, linearity and range, ruggedness, limit of detection & quantification, robustness, and precisión. Precisión was analysed by taking Reading interday and Intraday. Ruggedness was analysed by differant analyst and robustness by changing the solvent composition.
Authors and Affiliations
O. S. Shelke , K. S. Sable , V. S. Neharkar , B. V. Mathdevru
Keywords
Related Articles
- EP ID EP145614
- DOI -
- Views 107
- Downloads 0
ARTIFICIAL BLOOD: A TOOL FOR SURVIVAL OF HUMANS
Blood is a specialized body fluid that delivers necessary substances to the body cells such as nutrients and oxygen and transports waste products away from those cells. Artificial blood is supposed to fulfil some functi...
HIGH PERFORMANCE LIQUID CHROMATOGRAPHY DETECTORS – A REVIEW
HPLC is the most versatile and widely used elution chromatography. The technique is used to resolve and determine species in a variety of organic, inorganic, biological, ionic and polymeric materials. Detector is the hea...
BERBERIS ASIATICA FUTURE BASED EXCELLENT FRUIT IN NUTRITIONAL PROFILE, ANTIMICROBIAL AND ANTIOXIDANT INGREDIENTS
The aim of the present study was to calculate in vitro antimicrobial activity of Berberis asiatica fruit extracts against 13 Gram-positive and Gram-negative bacteria and fungus strains. The ethanolic fruit extracts of Be...
ANTINOCICEPTIVE AND ANTI-INFLAMMATORY ACTIVITIES OF CROTON SPARSIFLORUS MORONG LEAVES IN ANIMAL MODELS
A depth study was carried out to find out the potential of chloroform extract of Croton (C) sparsiflorus morong. (Family-Euphorbiaceae) leaves on antinociceptive, behavioral study and anti-inflammatory effects using var...
COMPARATIVE STUDY ON THE SUBSTITUTES USED IN AYURVEDA WITH SPECIAL REFERENCE TO SUBSTITUTES FOR PUSHKARAMULA (INULA RACEMOSA HOOK.F.) VIZ., KUSHTA (SAUSSUREA LAPPA DECNE.) AND ERANDAMULA (RICINUS COMMUNIS L.): A CLINICAL STUDY
Ayurvedic literature introduced several substitutes for the herbs which are either not available or which are not accessible for various reasons. On review of more than 35 texts and their commentaries it is found that th...