DEVELOPMENT AND VALIDATION OF A UV SPECTROPHOTOMETRIC METHOD FOR THE SIMULTANEOUS DETERMINATION OF NIFEDIPINE AND ATENOLOL IN COMBINED DOSAGE FORM
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2012, Vol 3, Issue 4
Abstract
Simultaneous estimation and validation of developed method of Nifedipine (NIF) and Atenolol (ATN) in combined dosage form as well as in laboratory mixture is studied under this paper. Nifedipine and Atenolol are used in combined dosage form for Cardiovascular System Diseases. The compound was identified by taking the IR spectra. The method is applied for laboratory mixture and marketed tablet. The developed method was validated as per ICH guidelines using the parameter such as accuracy, linearity and range, ruggedness, limit of detection & quantification, robustness, and precisión. Precisión was analysed by taking Reading interday and Intraday. Ruggedness was analysed by differant analyst and robustness by changing the solvent composition.
Authors and Affiliations
O. S. Shelke , K. S. Sable , V. S. Neharkar , B. V. Mathdevru
Keywords
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