DEVELOPMENT AND VALIDATION OF A UV SPECTROPHOTOMETRIC METHOD FOR THE SIMULTANEOUS DETERMINATION OF NIFEDIPINE AND ATENOLOL IN COMBINED DOSAGE FORM
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2012, Vol 3, Issue 4
Abstract
Simultaneous estimation and validation of developed method of Nifedipine (NIF) and Atenolol (ATN) in combined dosage form as well as in laboratory mixture is studied under this paper. Nifedipine and Atenolol are used in combined dosage form for Cardiovascular System Diseases. The compound was identified by taking the IR spectra. The method is applied for laboratory mixture and marketed tablet. The developed method was validated as per ICH guidelines using the parameter such as accuracy, linearity and range, ruggedness, limit of detection & quantification, robustness, and precisión. Precisión was analysed by taking Reading interday and Intraday. Ruggedness was analysed by differant analyst and robustness by changing the solvent composition.
Authors and Affiliations
O. S. Shelke , K. S. Sable , V. S. Neharkar , B. V. Mathdevru
Keywords
Related Articles
- EP ID EP145614
- DOI -
- Views 107
- Downloads 0
OPTIMIZATION OF ALPHA AMYLASE EXTRACTED FROM MARINE ACTINOMYCETES-STREPTOMYCES GANCIDICUS_ASD-KT852565
The crude extract obtained from Streptomyces gancidicus_ASD-KT852565isolated from marine actinomycetes soil sample which was collected from Andaman& Nicobar Island was subjected to optimization with 10 different para...
COMPARATIVE STUDY OF HIGH PERFORMANCE LIQUID CHROMATOGRAPHY AND ULTRAVIOLET SPECTROPHOTOMETRY METHODS ON DIFFERENT BRANDS OF METRONIDAZOLE TABLETS MARKETED IN MAIDUGURI METROPOLITAN COUNCIL OF BORNO STATE
The active ingredient of ten brands of Metronidazole tablets were determined using High Performance Liquid Chromatography and Ultra Violet Spectrophotometry to determine which of the assay methods is better and if the dr...
METHOD DEVELOPMENT AND VALIDATION FOR THE DETERMINATION OF ESOMEPRAZOLE IN TABLET DOSAGE FORM BY RP-HPLC METHOD
A simple, precise, rapid, and accurate RP-HPLC method has been developed to determine esomeprazole magnesium trihydrate using chromatographic separation isocratically on C18 column (5 μm, 150mm x 4.60mm) and acetonitri...
ARTIFICIAL BLOOD: A TOOL FOR SURVIVAL OF HUMANS
Blood is a specialized body fluid that delivers necessary substances to the body cells such as nutrients and oxygen and transports waste products away from those cells. Artificial blood is supposed to fulfil some functi...
STUDY OF DRUG LIKENESS ACTIVITY OF PHYTOCHEMICALS IN MEDICINAL PLANTS
Phytochemicals in medicinal plants can deliver potential therapeutic drugs such as anticancer, antiviral, antioxidant etc. The plant kingdom is a treasure house of potential drugs and each phytochemical cannot be tested...