STUDY OF DRUG LIKENESS ACTIVITY OF PHYTOCHEMICALS IN MEDICINAL PLANTS
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2012, Vol 3, Issue 11
Abstract
Phytochemicals in medicinal plants can deliver potential therapeutic drugs such as anticancer, antiviral, antioxidant etc. The plant kingdom is a treasure house of potential drugs and each phytochemical cannot be tested in the wetlab preparations. Hence the main aim of the study is the drug likeness activity of phytochemicals in medicinal plants such as Anethum graveolens, Apium graveolens against hepatocellular carcinoma. These plants have anticancer, antilivercancer, hepatoprotective, antiviral activities. Focusing on these activities, the phytochemicals from these plants were collected from Dr.Duke Phytochemical and ethnobotanical database. The drug likeness is evaluated by satisfying Lipinski’s rule of five, ADMET properties, Partition coefficient analyzed through Accelerys Discovery studio. The results screen the phytochemicals and these interpretations can be further preceded for the drug designing.
Authors and Affiliations
V. Sathya, V. K. Gopalakrishnan
Keywords
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