EVALUATION OF ANTI-ANXIETY ACTIVITY OF ACTAEA SPICATA LINN.
Journal Title: International Journal of Pharmaceutical Sciences and Drug Research - Year 2011, Vol 3, Issue 1
Abstract
Actaea spicata Linn. (Ranunculaceae) has been traditionally used for the treatment of various ailments such as rheumatism, inflammation, nerve diseases, lumbago, scrofula and chorea. Despite a long tradition of use, no systematic phytochemical and pharmacological work has been carried out on this potential plant. Thus, A. spicata was subjected to preliminary anti-anxiety screening studies, with a view to ascertain the verity of its traditional use as an anxiolytic. In the present investigation, roots of the plant were extracted using solvents in order of increasing polarity viz., petroleum ether (60-80C), chloroform, methanol and distilled water. All the crude extracts were evaluated for anti-anxiety activity in mice using elevated plus maze apparatus. Among all these extracts, only methanol extract exhibited significant anti-anxiety activity at a dose of 100 mg/kg in mice with respect to control as well as standard (diazepam, 2 mg/kg). Phytochemical screening showed presence of alkaloids and polyphenols in methanol extract of A. spicata. Thus, Specific methods were adopted to extract total alkaloidal and polyphenol fractions from the plant material and methanol extract of plant, respectively. Polyphenol fraction exhibited significant anxiolytic activity at the dose of 50 mg/kg, while alkaloidal fraction was found to be devoid of any activity.
Authors and Affiliations
Reecha Madaan, Anupam Sharma
Keywords
Related Articles
- EP ID EP624989
- DOI -
- Views 50
- Downloads 0
DETERMINATION OF THE RUTIN, QUERCETIN AND KAEMPFEROL CONTENTS IN A GHANAIAN POLYHERBAL FORMULATION (EAF-2011) AND ITS RAW MATERIALS USING A SIMULTANEOUS RP-HPLC METHOD
Quantitative chemical fingerprinting of herbal medicines provides an avenue for addressing the challenge with their quality. In this report, chemical markers that could be labelled as active markers in the polyherbal pro...
PROGRESS AND PROSPECTS IN THERAPEUTICS AGAINST HIV INFECTION
Tremendous advances have occurred in recent decades in the development of safe and effective medications for the treatment of viral diseases. Currently there are more than 20 HIV drugs approved for use in humans. Combine...
THERAPEUTIC ACTIVITY OF POLYHERBAL FORMULATION AGAINST PASSIVE ANAPHYLAXIS BY USING RAT MESENTERIC MAST CELLS
Anaphylaxis is the result of alteration in mast cell physiology and is responsible for the various physiological changes which are observed during anaphylaxis. The symptoms of anaphylaxis are due to the release of the hi...
DISCOVERY OF SOME EMERGING FREE RADICAL SCAVENGING CANDIDATES BEARING 2-(P-HYDROXYPHENYL)-4–(SUBSTITUTEDPHENYL)-1H-1,5–BENZODIAZEPINES PHARMACOPHORE
In the present investigation, the synthesis of few novel leads bearing 2-(p-hydroxyphenyl)-4–(substitutedphenyl)-1H-1,5–benzodiazepine pharmacophore is described. The substituted chalcone and their derivatives 3(a-j) wer...
BIOACTIVITY AND DEREPLICATION OF PHENOLIC COMPOUNDS IN MEDICINAL PLANTS
Three medicinal plants with recognized anti-inflammatory potential, identified as “erva de São João“ (Ageratum conyzoides), “Tanchagem“ (Plantago major) and “ Bardana“ (Arctium lappa L.) were obtained from a medicinal he...