Evaluation of anti-arthritic activity of aqueous extract of leaves of chloroxylon swetenia in adjuvant induced arthritis in rats
Journal Title: International Journal of Research in Pharmacology & Pharmacotherapeutics (IJRPP) - Year 2015, Vol 4, Issue 3
Abstract
OBJECTIVE The aim of this study was to evaluate anti-arthritic activity of ethanolic extract of Chloroxylon swietenia leaves in Male Wister Albino rats using in-vitro and in-vivo methods. METHODS Animals were divided into five groups of six animals each as follows: GROUP-I - Normal rats given vehicle alone 2% Tween 80, (p.o). GROUP-II -Arthritic untreated rats. GROUP-III -Arthritic rats treated with 10mg/kg (p.o) standard Diclofenac sodium. GROUP-IV -Arthritic rats treated with 100mg/kg (p.o) of ethanolic extract. GROUP-V –Arthritic rats treated with 200mg/kg (p.o) of ethanolic extract. The inducing agent used was Complete Freund's adjuvant (CFA). The biochemical parameters like erythrocyte sedimentation rate (ESR), red blood cell (RBC), Hemoglobin (Hb), and total WBC count was observed which were the major markers of arthritis and uric acid analysis (plasma). A significant inhibition of paw edema volume and body weight was observed from day 0th, 7th, 14th, 21st and 28th day in the treated groups. RESULTS A significant increase in body weight, reduction in paw volume of both hind legs were observed in FCA induced arthritis rats. A decrease in levels of RBC and hemoglobin were observed in arthritic rats. There was a significant improvement in the levels of hemoglobin and RBC in Chloroxylon swietenia treated rats. The increased levels of WBC, ESR were significantly suppressed in the extract administered arthritic group. CONCLUSION It may be concluded that the ethanolic extract of Chloroxylon swietenia at two different concentrations (100mg/kg and 200mg/kg) possessed significant anti-arthritic activity as compared to standard drug.
Authors and Affiliations
Goverdhan Reddy Puchchakayala
Keywords
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