Evaluation of anti-diabetic activity of syzygium cumini on streptozotocin induced diabetes in rats
Journal Title: International Journal of Research in Pharmacology & Pharmacotherapeutics (IJRPP) - Year 2018, Vol 7, Issue 3
Abstract
Aim and objectives To evaluate the anti-diabetic activity of Syzygium cumini seed powder extract on streptozotocin induced diabetes in rats. Materials and Methods Wister Albino rats weighing 230-250gm were divided in to 5 groups. Diabetes induced in four groups by administration of streptozotocin (45mg/kg/i.p). G-I severs as control and normal saline was administered. G-II diabetic control, G-III Diabetic control (Streptozotocin 45mg/kg/i.p/0day) + Glibenclamide (5mg/kg/orally/120 days), G-IV: Diabetic control (Streptozotocin 45mg/kg/i.p/0day)+ Aqueous extract of Syzygium cumini seeds (250mg/kg/orally/120 days) and G-V: Diabetic control (Streptozotocin 45mg/kg/i.p/0day) + Aqueous extract of Syzygium cumini seeds (500mg/kg/orally/120 days). All the drugs were respective groups for 120 days. Blood was collected from the groups at different time intervals (0day. 15th day, 30th day, 60th day and 120th day). Plasma was separated and used for estimation of glucose. Results Comparison of glucose values of control group with other groups showed that there was significant decrease in glucose values in other groups p<0.05. But 15th day group-III and V showed significant decrease in glucose level compared to group-IV. G-V showed decrease glucose levels compared with other groups at 30th, 60th and 120th day. Comparison on 0 day between groups showed insignificant difference in blood glucose level (P>0.05). Conclusion High dose of S.C seed extract showed results like standard oral hypoglycemic drug. There is a requirement of more studies on this plant seed to find active phytochemicals.
Authors and Affiliations
Swadhin Ranjan Behera
Keywords
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