Evaluation of Anti-Hyperglycaemic Potential of Allium Cepa, Coffee and Oxidative Stress
Journal Title: International Journal of Biochemistry & Physiology - Year 2018, Vol 3, Issue 1
Abstract
Allium cepa Linn, botanicals, Liliaceae (family) commonly known as onion, and coffee are special delicacies, and conventional as functional foods that contain physiologically active ingredients that for centuries have been exploited as folk remedies for the treatment of diseases. The present study was conducted to evaluate the therapeutic efficacies and the possible participation of oxidative stress of Nigerian Allium cepa and coffee such as antioxidant, antihyperglycaemic, hypoglycaemic, hyperglycaemic in normal experimental wistar rats. Materials and Methods: qualitative phytochemical screening of hydromethanolic extract of Allium cepa was carried out for the identifications of the phytoconstituents. Hydromethanolic extract of Allium cepa 100mg kg -1, vitamin E 400mg kg -1, and coffee 500mg kg-1, combinations of Allium cepa and coffee and vitamin E and coffee respectively, administered orally to each group of rats daily. During the experimental periods glucose concentrations were estimated at baseline 0 (time of treatment ingestion), age 21 and 42 days respectively, with corresponded oxidative stress markers - superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), glutathione (GSH) and malondialdehyde (MDA) analyzed at age 42 days. Results: Result ranked time-dependent (in days) glucose lowering potential of treatments as: - Allium cepa + coffee > Allium cepa > vitamin E > coffee + vitamin E; with corresponded up regulated of SOD, CAT, GPx and GSH and reduced MDA. onversely, coffee and control group (normal rats) significantly in time – dependent, raised blood glucose level with corresponded increase in MDA with respect to other biomarkers, suggesting lipid peroxidation oxidative stress induced impairment of cellular antioxidant protective system. Conclusion: It can be concluded that synergistic effect, presence of the additive bioactive phytoconstituents, and/or antioxidant efficacies or both, and potentiation action of several compounds in Allium cepa and coffee combined , over time, offer the intrinsic antioxidant defence system much better defensive mechanism to protect against free radicals, and alleviate the toxic effects of accumulation of reactive oxygen species (ROS); thence providing protective mechanisms against the development of elevated blood sugar levels. Evidently, Allium cepa and coffee combined isefficacious and potent hypoglycemic agent, which could be beneficial as a dietary supplement for prevention, treatment or management of raised blood glucose levels or diabetes.
Authors and Affiliations
Chuemere AN
Keywords
Related Articles
- EP ID EP396077
- DOI 10.23880/ijbp-16000116
- Views 53
- Downloads 0
Resurrection of the Fern "Cheilanthes albomarginata Clarke" Involves Utilization of Trehalose as Energy Source and Accumulation of Protective Stress Metabolites
Most plants are unable to survive desiccation to an air-dried state, but a small group of plants known as resurrection plants can tolerate extreme desiccation, and regain normal function after rehydration. Cheilanthes al...
Role of Antioxidant-Rich Nutraceutical on Body Weights and Mean Arterial Blood Pressure of Salt-Induced Hypertensive Rats
Hypertension or high blood pressure is a medical condition in which blood pressure in the vessels is persistently elevated. The study aim to formulate an antioxidant rich nutraceutical from locally available food stuff (...
Investigation of Antidiarrheal Activity of the Aqueous Leave Extract of Ficus asperifolia in Rats
Ficus asperifolia (FA) has been recommended locally for several disorders including diarrhea. Although various work had been done on Ficus asperifolia but not on it antidiarrhea activity. The objective of this research i...
Ferritin Heavy Chain: From Redox Cycling to Cancer Biology
Iron is an essential nutrient for physiological cellular functions: as cofactor for key enzymes, it is involved in DNA duplication and repair thus representing a key element for cell replication, metabolism and growth. D...
Biofilm Effect and Growth of Waste Frying Oil (WFO) on Bacteria
Every year in the world, waste frying oils that are released into the environment without using a large amount or recycling can create a big environmental problem. Waste oils may be an alternative, especially for studies...