EVALUATION OF ANTI-HYPERTROPHIC POTENTIAL OF CAMELLIA SINENSIS IN ISOPROTERENOL INDUCED CARDIAC HYPERTROPHY
Journal Title: International Journal of Pharmacy and Pharmaceutical Sciences - Year 2018, Vol 10, Issue 10
Abstract
Objective: Camellia sinensis (C. sinensis family-Theaceae) has potent antioxidant activity used in the treatment of cardiovascular disease. The present study evaluates the cardioprotective (anti-hypertrophic) effect of aqueous extract of C. sinensis in isoproterenol (ISO) induced cardiac hypertrophic rats.Methods: The beneficial effect of the green tea extract was examined by the administration of the aqueous extract of the leaves of C. sinensis (100 mg/kg b.w., oral., 7 d) in ISO (10 mg/kg b.w., subcutaneous.,7 d) induced cardiac hypertrophic rats with reference to the standard drug, losartan (50 mg/kg b.w., oral.,7 d) followed by biochemical estimations of glucose, protein, cholesterol, cardiac marker enzymes namely serum glutamate oxaloacetate transaminase (SGOT), serum glutamate pyruvate transaminase (SGPT) and lactate dehydrogenase (LDH) in serum and heart tissues thus collected at the end of 7 d.Results: The biochemical assays revealed significantly (P<0.05) increased glucose, protein, cholesterol, cardiac marker enzymes namely serum glutamate oxaloacetate transaminase (SGOT), serum glutamate pyruvate transaminase (SGPT) lactate dehydrogenase (LDH) and significantly (P<0.05) decreased in ISO induced cardiac hypertrophic rats that were reciprocated by the effect of plant extract.Conclusion: Thus, this study showed that the aqueous leaf extract of C. sinensis possesses potent effect against cardiac hypertrophy. This potential is hypothesized to be due to the phytochemical, Catechin present in the plant that requires further isolation and characterization with respect to anti-hypertrophic therapeutics.
Authors and Affiliations
Doss V. A. , Jeevitha Parthibhan, Dharaniyambigai Kuberapandian
Keywords
Related Articles
- EP ID EP566139
- DOI 10.22159/ijpps.2018v10i10.28101
- Views 84
- Downloads 0
BRAZILEIN INCREASES THE SENSITIVITY OF DOXORUBICIN ON MCF-7 RESISTANT DOXORUBICIN (MCF-7/DOX) CELLS THROUGH INHIBITION OF HER-2 ACTIVATION
Objective: Brazilein is a compound obtained in a large amount from the dried heartwood of Secang (Caesalpinia sappan L.). Brazilein has strong cytotoxic effect in several cancer cell lines. This study was designed to eva...
MOLECULAR DYNAMICS GUIDED 4D QSAR STUDIES ON CHROMENONE BASED DNA-DEPENDENT PROTEIN KINASE INHIBITORS
Objective: Developing 4D QSAR model for chromenones as DNA-protein kinase inhibitors with LQTAgrid program and MATLAB with PLS Tool box.Methods: 2D structures of forty five chromenones and pyrimido [2,1-a] isoquinolin-4-...
STUDY ON VARIATIONS IN THE BRANCHING PATTERN OF ARCH OF AORTA
The most common branching pattern of the aortic arch in humans comprises of three great vessels, during the routine dissection for 1st MBBS we encountered variations in the branches of arch of aorta, so the study was con...
ISOLATION OF CYTOTOXIC CONSTITUENT FROM BIOACTIVITY GUIDED FRACTION OF ALYSICARPUS MONILIFER L. (DC.)
Objective: Alysicarpus monilifer (Family Papilionaceae) has been used in the Indigenous system of medicine in tumor removal. The present study was designed to isolate and identify the constituent responsible for cytotoxi...
IMMUNOMODULATORY EFFECT OF DIFFERENT PROPORTIONS OF THE HERBAL MIXTURE IN TRIPHALA ON HUMAN T LYMPHOCYTES (MOLT-4)
Objectives: To investigate effect of different proportions of Terminalia bellerica Roxb (TB):Terminalia chebula Retz (TC):Phyllanthus emblica L. (PE) in triphala extract on immunological activity and to determine the pos...