EVALUATION OF ANTI-INFLAMMATORY ACTIVITY OF LALAB PURPUREOUS METHANOLIC LEAVES EXTRACT ON WISTER ALBINO RATS
Journal Title: INTERNATIONAL JOURNAL OF MODERN PHARMACEUTICAL RESEARCH - Year 2018, Vol 2, Issue 5
Abstract
This work has been done for the investigation of the anti-inflammatory activity of solvent extracts of dried leaves of Lalab purpureous linn. by oral administration at dose of 200 and 400 mg/kg body weight in healthy albino rats. Extracts were studied for its anti-inflammatory activity by using formalin and egg white albumin induced right hind paw edema in albino rats and the mean increase in paw volume and % inhibition in paw volume were measured plethysmometrically at different time intervals after 20μl of (2.5% solution) injection. The methanol extract showed significant (P < 0.001) reduction in the formalin and egg white induced paw edema in comparison to aqueous extracts. Petroleum ether and hexane extracts showed no reduction in paw edema. The methanol extract showed anti-inflammatory effect in dose dependent manner when compared with the control and standard drug, Diclophenac sodium (10mg/kg, p.o). The human red blood corpuscular membrane is similar to lysosomal membranes that influence inflammatory process. Result obtained using methanolic extract of Lalab purpureous Linn. have better acceptance as it shows good response in inhibiting haemolysis (33.15%) at highest concentration These inhibitions were statistically significant (p < 0.05). Thus our investigation suggests a potential benefit of methanol and aqueous extracts of leaves of Lalab purpureous linn in treating conditions associated with inflammation. This study illustrates about the presence of some active polar compounds in the leaves extracts which might be responsible for antiinflammatory activity.
Authors and Affiliations
G. Rajyalakshmi
Keywords
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