Evaluation of Anti-inflammatory and Immunosuppressive Activities of Indomethacin in Experimental Animal Models
Journal Title: Indian Journal of Pharmacy and Pharmacology - Year 2016, Vol 3, Issue 4
Abstract
Background: A potent non selective non-steroidal anti-inflammatory drug(NSAIDs) is indomethacin commonly not used as first line analgesic in clinical practice due to its adverse drug reactions. Acute anti-inflammatory and Immunomodulatory activity of the drug has already been studied. But we had set forward our study to establish these properties in experimental animals. Objectives: Evaluation of anti-inflammatory and immunosuppressive activities of Indomethacin in experimental animal models. Methods: In each group 12 rats were taken as experimental animals. Dexamethasone was used as standard drug in model of chronic inflammation and water as vehicle control. Indomethacin in different doses was used as standard drug. The following models of inflammation were employed: Carrageenan-and Dextran induced acute oedema (measured between 30 min and 4 h) in rat paw, and Freund’s adjuvant induced arthritis (oedema measured on 21st day). Results: Indomethacin at a dose of 10 mg/Kg of body weight showed significant inhibitory response in carrageenan and dextran induced rat paw edema in comparison to vehicle control in our study (87.3% and 91.5%, respectively). In arthritic model 1 mg/kg of Indomethacin showed significant chronic anti-inflammatory effect (29%) in comparison to vehicle control .Standard drug dexamethasone showed (84.6%) of immunosuppressive effects on 21st day. Conclusion: These data support the fact that Indomethacin has both acute anti-inflammatory and chronic anti-inflammatory (immunosuppressive) activity.
Authors and Affiliations
Chandan Chatterjee
Keywords
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