EVALUATION OF ANTI-INFLAMMATORY EFFECT OF CALOTROPIS PROCERA PROCERA (AIT.) R.BR. ROOT EXTRACT AGAINST DIFFERENT MEDIATORS OF INFLAMMATION IN ALBINO RATS
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2011, Vol 2, Issue 3
Abstract
Calotropis procera (Ait) R Br had been widely used for its reported biological activities in indigenous system of medicine. The present investigation was carried out to find the effect of methanolic extract of root of Calotropis procera for its anti-inflammatory activity in rodents.The anti-inflammatory activity was evaluated using acute inflammatory models like; carrageenan induced paw oedema, and chronic models like; cotton-pellet induced granuloma, Turpentine oil-induced granuloma pouch and Formalin-induced oedema in rats. Oral administration of the extract at the doses 200 and 400 mg/kg b.w.p.o. exhibited dose dependent and significant anti-inflammatory activity in acute (carrageenan- induced hind paw oedema, p < 0.05) and chronic (cotton pellet granuloma, Turpentine oil-induced granuloma pouch and Formalin-induced oedema models, p < 0.05) of inflammation. Hence, present investigation established some pharmacological evidences to support the folklore claim that C.Procera is used as anti-inflammatory agent.
Authors and Affiliations
Prakash Patil , K Prasad , M Nitin , Vijay Kumar, Sreenivasa Rao
Keywords
Related Articles
- EP ID EP108511
- DOI -
- Views 98
- Downloads 0
ASSESSING THE PATTERN OF DRUG USE AMONG PREGNANT WOMEN AND EVALUATING THE IMPACT OF COUNSELLING ON MEDICATION ADHERENCE AMONG THEM
In the present study an attempt is made to assess the pattern of drug use among pregnant women and to evaluate the impact of counseling on medication adherence by providing patient education regarding pregnancy. During t...
EVALUATION OF ANTIFUNGAL ACTIVITY OF NEOLAMARCKIA CADAMBA (ROXB.) BOSSER LEAF AND BARK EXTRACT
The present study was designed to evaluate the antifungal activity of alcoholic and aqueous extract from leaves and bark of Neolamarckia cadamba (Roxb.) Bosser using the paper disc diffusion method. All the extracts show...
COMPARATIVE IN VITRO RELEASE STUDY OF SOME COMMERCIALLY AVAILABLE FLUCONAZOLE TABLETS
Sundry brands of same dosage forms are available in the Indian market with the common assertion that they are all bioequivalent. The main objective of the present study was to conduct the comparative dissolution studies...
MICROBIOLOGICAL EXAMINATION OF SCLICED FRUITS SOLD IN MINNA METROPOLIS
Fresh cut fruits processed by peeling, slicing or trimming with or without further processing or cooking before consumption. Fresh cut fruits collected from different stationary vendors and hawkers in Minna metropolis we...
DEVELOPMENT AND IN VITRO EVALUATION OF MOUTH DISSOLVING FILMS OF CAPTOPRIL
Captopril is a potent, competitive inhibitor of angiotensin-converting enzyme(ACE), the enzyme responsible for the conversion of angiotensin I (AT I) to angiotensinII (AT II). Captoprilmaybeusedinthetreatmentofhypertensi...