Evaluation of anti-oxidant and oxidative stress parameters in chronic obstructive pulmonary disease
Journal Title: International Journal of Clinical Biochemistry and Research - Year 2018, Vol 5, Issue 1
Abstract
Introduction: Chronic obstructive pulmonary disease (COPD) is an important lung disorder. Tobacco smoking accounts for 80% of patients of COPD cases and the remaining 20% are due to exposure to environmental tobacco smoke, occupational dusts and chemicals, and indoor air pollution from biomass fuel used for cooking and heating in poorly ventilated buildings. The oxidative stress seen with COPD patients is due to the oxidants present in cigarette smoke and from increased amounts of reactive oxygen species released from leucocytes, from both in air spaces and blood. Materials and Methods: This was prospective, case-control study conducted at a tertiary care teaching hospital (medicine department) from April 2015 to August 2015. After obtaining written informed consent a total of 84 participants were explained about the study. The anti-oxidant parameters i.e. Vitamin C and E, superoxide dismutase, whole blood reduced glutathione and oxidative stress markers i.e. malondialdehyde, serum nitric oxide were measured both in COPD patients and controls. The study was approved by institutional ethics committee. The results are expressed as mean and standard deviation of the parameters evaluated. The unpaired âtâ test wass used for comparing different biochemical parameters between cases and controls. The p value of < 0> Results & Discussion: There was no statistically significant difference in the demographic data between the cases and controls. Maximum patients were in stage 3 COPD. Tobacco smoking is an important cause for development of COPD by formation of reactive oxygen species and other free radicals There was statistically significant difference (p<0> Conclusion: The results of the present study indicate a disturbance in oxidant/antioxidant status in COPD patients. The periodic measurements of oxidative stress markers and antioxidant status in COPD patients might be useful in prognosis of the disease. These results may contribute for the development of novel therapeutic interventions.
Authors and Affiliations
Pampareddy B Kollur, Kiran Kumar Akka, Basawarajeshwari P Kollur, Sangappa Virupaxappa Kashinakunti
Keywords
Related Articles
- EP ID EP472040
- DOI 10.18231/2394-6377.2018.0003
- Views 34
- Downloads 0
Effect of elevated iron stores on lipid profile in patients of type 2 diabetes mellitus
Introduction Diabetes Mellitus DM comprises a group of metabolic disorders presenting with hyperglycemia resulting from insulin deficiency or decreased glucose utilization and increased glucose production Ferritin is a g...
Comparison of glucose levels using glucometer and GOD-POD Method in diabetic patients
Introduction: Glucometer is widely used at hospitals and homes as a first line tool to get an idea about the current blood glucose levels. Since glucometers are used for making important decisions, it is essential that t...
Serum lactate as a predictor of outcome of sepsis â study
Introduction: Serum Lactate is known to be elevated in subjects with sepsis. Increased blood lactate levels are common in critically ill patients. Some studies revealed its association with prediction of morbidity and mo...
Speculation of diabetic nephropathy by pro-inflammatory cytokines (IL-6, IL-10) & renal biomolecules
Introduction: Type 2 diabetic nephropathy (T2DN) develops inflammation in kidney which leads to failure. Study designed to evaluate risk of diabetic nephropathy (DN) by inflammatory gene expressions (IL6, IL10) and renal...
Educating people about the healthy edible oils and its storage practices can reduce the incidence of metabolic syndrome: A KAP study
Background: The use of edible oils depends on the traditional practices, educational and socio-economic status. There is a need to educate people regarding the harmful effects of saturated, trans fatty acids, proper stor...