EVALUATION OF ANTI-THYROID ACTIVITY OF FICUS RACEMOSA LINN BARK IN MALE RATS
Journal Title: International Journal of Pharmacy and Pharmaceutical Sciences - Year 2015, Vol 7, Issue 3
Abstract
Objective: The present study was formulated in order to evaluate the Antithyroid potential of Ficus racemosa Linn bark in Albino rats.Methods: Ficus racemosa (L.) (Family: Moraceae), is used in the mythical system for abortion, diabetes and urinary disorders. The genus of Ficus exhibited the presence of tyrosine which is responsible for the formation of T3 and T4 hormones. Hyperthyroidism was induced in experimental rats by administering Thyroxine (600µ/kg/ml) orally for 14 days. Hyper thyroid male albino rats weighing 150-200 g were treated with oral doses of 250 mg/kg, 350 mg/kg and 450 mg/kg of Ficus racemosa ethanolic extract for a period of 21 days. Methimazole 0.04% w/v for 21 days served as the standard.Results: In this study, morphological assessment demonstrated that thyroxine treated gathering demonstrates increased levels of Triiodo-L-thyronine and L-thyroxine. Simultaneous administration of ethanolic extracts of Ficus racemosa bark lowered the increased levels. The decrease in the levels of T3 and T4 by the extracts was compared with the reference drug Methimazole.Conclusion: The Antithyroid activity is evident from the decreased T3 and T4 levels. It can be said that Ficus racemosa significantly by virtue of the presence of tyrosine, which may be useful for further molecular studies to determine the exact mechanism for its Antithyroid activity.Â
Authors and Affiliations
Mohammed Azharuddin, Mohammed Ibrahim Ahmed, Syed Asadulla Bakhtiary
Keywords
Related Articles
- EP ID EP578944
- DOI -
- Views 68
- Downloads 0
EVALUATION OF INNOVATIVE CO-PROCESSED ADDITIVE FOR DIRECT COMPRESSION TABLETS USING ATORVASTATIN AND DIAZEPAM AS MODEL DRUGS
Objective: The aim of the present study is to prepare and evaluate a co-processed excipient from commercially available Avecil PH102 and silicon dioxide colloidal (SDC) using direct compression technique for preparation...
ASSESSMENT OF OSTEOPOROSIS AND ANAEMIA RISK IN PATIENTS ON ANTICONVULSANT THERAPY
Objective: To assess the incidence of osteoporosis and anaemia in patients on anticonvulsant therapy and to educate those under risk.Methods: A prospective observational study was conducted on 50 study participants. The...
ELECTROCHEMICAL AND CHEMOMETRIC DETERMINATION OF DORZOLAMIDE AND TIMOLOL IN EYE DROPS USING MODIFIED MULTIWALL CARBON NANOTUBE ELECTRODE
Objective: This work is focused on the construction of simple and sensitive electrochemical sensor for quantitative determination of dorzolamide (DOR) and timolol maleate (TIM). This method is based on the incorporation...
IN VITRO CYTOTOXICITY EFFECT ON MCF-7 CELL LINE OF CO-ENCAPSULATED ARTESUNATE AND CURCUMIN LIPOSOME
Objective: Cancer drug delivery has focused using novel carrier system due to their high drug loading and release controlled property and minimum side effect. Artesunate (ART) and curcumin (CUR) are proved natural herbal...
INVESTIGATION OF THE ANTIBIOTIC RESISTANCE: THE CASE OF BUU DIEN GENERAL HOSPITAL IN HO CHI MINH CITY
Objective: In Vietnam, antibiotic resistance has been gained the attention of medical professionals in antibiotic use management. This study aimed to investigate the antibiotic resistance among hospital-acquired infectio...