Evaluation of Anti-ulcer activity of methanolic extract of Terminalia chebula fruits in experimental rats
Journal Title: Journal of Pharmaceutical Sciences and Research - Year 2009, Vol 1, Issue 3
Abstract
The anti-ulcer activity of methanolic extract of Terminalia chebula (Combretaceae)fruits METC was investigated in pylorus ligation and ethanol induced ulcer models in wistar rats. In both models the common parameter determined was ulcer index. METC at doses of 250,500 mg/kg p.o produced significant inhibition of the gastric lesions induced by Pylorus ligation inducedulcer & Ethanol induced gastric ulcer .The extract (250 mg/kg & 500 mg/kg) showed significant (P<0.01) reduction in gastric volume, free acidity and ulcer index as compared to control. This present study indicates that Terminalia chebula fruit extract have potential anti ulcer activity in the both models. These results may further suggest that methanolic extract was found to possess antiulcerogenic as well as ulcer healing properties, which might be due to its antisecretory activity.
Authors and Affiliations
Raju D. , Ilango K. , Chitra V. , Ashish K.
Keywords
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