Hepatoprotective and antioxidant effect of Sphaeranthus indicus against acetaminophen–induced hepatotoxicity in rats.
Journal Title: Journal of Pharmaceutical Sciences and Research - Year 2009, Vol 1, Issue 2
Abstract
The flower heads of Sphaeranthus indicus Linn (Asteraceae) a traditional Indian medicinal plant iscommonly used to nourish and improve the liver conditions. This study was designed to evaluate thehepatoprotective and antioxidant effect of aqueous (AQS) and methanolic (MES) extract of flower heads ofSphaeranthus indicus on Acetaminophen (APAP)-induced heptotoxicity in rat’s in-vivo. Activities of livermarker enzymes ,glutamate-oxaloacetate transaminase (SGOT) glutamate pyruvate transaminase (SGPT),acid phosphatase (ACP) and alkaline phosphatase (ALP) bilirubin and total protein at an oral dose of MES(300mg/kg) showed a significant hepatoprotective effect in comparison with the same dose of aqueousextract. This fact was also confirmed by studying the liver histopathology of treated animals. As Regardsthe antioxidant activity, MES exhibited a significant effect showing increasing levels of superoxidedismutase (SOD), Catalase (CAT), and glutathione peroxides (GPX) by reducing malondialdehyde (MDA)levels.
Authors and Affiliations
Brijesh K. Tiwari, Khosa R. L.
Keywords
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