Evaluation of Antibacterial Activity and Synergistic Effect of Different Conventional Antibiotics against Diarrheal Bacteria
Journal Title: Scholars Academic Journal of Pharmacy - Year 2018, Vol 7, Issue 1
Abstract
Abstract: The present study has been carried out to evaluate the activity of antibiotics alone and antimicrobial potential of their combination against bacteria implicated in infectious diseases like diarrhoea in tropical areas. The antimicrobial potential of antibiotics was tested against clinical isolates and reference bacterial strains using disk diffusion and microdilution methods. The results showed that the combined application of the antibiotics led to a synergistic effect in some cases, but antagonistic effect was also observed in some bacteria. Combinations involving CIP together with another antibiotic were the most efficient. Combinations CIP+MTZ and AMX+CIP were synergistic and have bactericidal activity against S. aureus, P. aeruginosa, respectively. While the synergistic combination of CIP+AMP was bactericidal against S. aureus and P. aeruginosa (MBC / MIC = 1). The use of the antibiotic combination depends on the antibiotics used and the infectious bacterial strain. The choice of antibiotic combinations should be dictated by results of susceptibility tests performed on each strain.
Authors and Affiliations
Joseph Privat Ondo, Guy Stéphane Padzys, Cédric Sima Obiang, Guy-Roger Ndong Atome, Morel Essono Mintsa, Rebecka Emmanuelle Moungoyi Massala, Louis-Clément Obame Engonga, Joel-Fleury Djoba Siawaya
Keywords
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