EVALUATION OF ANTICONVULSANT ACTIVITY OF ROOTS AND RHIZOMES OF CYPERUS ROTUNDUS LINN. IN MICE
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2011, Vol 2, Issue 10
Abstract
The aim of the present study was to evaluate the effects of Cyperus rotundus (CR) roots and rhizomes on seizures induced by pentylenetetrazol (PTZ) and picrotoxin (PTX). Pretreatment with hydroalcoholic extract of Cyperus rotundus (CR) roots and rhizomes (50-200mg/kg) induced a dose-dependent decrease in the incidence of both clonic and generalized tonic–clonic seizures (P≤0.05) following PTZ and PTX administration. Co-administration of a sub-effective dose of CR (50 mg/kg, po) with a sub-protective dose of diazepam (0.5 mg/kg, ip) increased the latency to seizure. The combination significantly enhanced percent protection against PTZ and PTX induced convulsions. The results suggested that the anticonvulsant effect of Cyperus rotundus (CR) roots and rhizomes against PTZ and PTX induced convulsions may be mediated, at least partly, through GABAA-benzodiazepine receptor complex.
Authors and Affiliations
Mayur Porwal , Pawan Prakash , Ashwin Saxena , Pravesh Sharma
Keywords
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