EVALUATION OF ANTIDEPRESSANT ACTIVITY OF ALOCASIA MACRORRHIZOS ON MICE
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2013, Vol 4, Issue 6
Abstract
The increased prevalence of depression at 12.3% rate and side effect profile of the existing antidepressants led to the present study which was designed to establish the role of natural herbal medicine Alocasia macrorrhizos as an antidepressant and to extend these results before the safe application in humans. 48 Albino male mice were divided into 2 sets each consisting of 4 groups with 6 animals in each group. Group1and 2 served as control and standard where as group3 and 4 were treated with hydroalcoholic extract of Alocasia macrorrhizos at the dose of 250mg/kg and 500mg/kg respectively. Drugs were suspended in 1% gumacasia and administered to mice orally one hour before test procedure. Forced swim test and tail suspension tests were standard animal models used for assessing antidepressant activity by recording the immobility time. Results from the study showed that hydroalcoholic extract of Alocasia macrorrhizos had significantly reduced immobility duration at the dose of 250mg/kg and 500mg/kg where it has shown better result than control group when subjected to the test procedures. Significant difference in immobility duration were noticed when these groups were compared to standard imipramine and there was a definite antidepressant effect observed with AM 500mg/kg whereas AM 250mg/kg values were comparable to imipramine. Hence we have concluded from the results of the study that hydroalcoholic extract of leaves of Alocasia macrorrhizos has the definite antidepressant effect which is comparable to Imipramine at 250mg/kg dose.
Authors and Affiliations
Ramya Kateel , Mohandas Rai , Akshaya Alva , Aiswarya Aravind , Pooja Prajwal
Keywords
Related Articles
- EP ID EP109444
- DOI 10.7897/2230-8407.04626
- Views 90
- Downloads 0
COMPARATIVE ANALYSIS OF PHYTOCONSTITUTIONAL AND PHARMACOLOGICAL ACTIVITIES OF DIFFERENT SEASONAL TEA LEAVES EXTRACTS
Methanolic extract of tea leaves (Camellia sinensis Linn.) of autumn and rain collections (SA and SR respectively) were investigated for in vitro antioxidants, antibacterial and wound healing activities to correlate with...
PREFORMULATION STUDIES OF SIMVASTATIN FOR TRANSDERMAL DRUG DELIVERY SYSTEM
The aim of the present work to study the preformulation parameters for Transdermal drug delivery system. The objective of Preformulation study is to generic information useful to the formulater in developing stable an...
PREPARATION AND EVALUATION OF BIODEGRADABLE ALBUMIN MICROSPHERES OF KETOROLAC TROMETHAMINE
The objective of the present study is to prepare sustained-release ketorolac tromethamine microspheres of bovine serum albumin in different ratios by the emulsion cross-linking method using epichlorohydrin. The prepared...
A RETROSPECTIVE EPIDEMIOLOGICAL ANALYSIS OF MALARIA IN SOUTH INDIAN TERTIARY CARE HOSPITAL
Malaria is a vector-borne infectious disease caused by parasitic protozoa of the Plasmodium type. The objective of our study was to analyze the extent of malaria cases and also to assess the factors associated with the o...
FORMULATION AND EVALUATION OF NOVEL ANTI-BACTERIAL CIPROFLOXACIN LOADED NIOSOMAL CREAM
The development of Ciprofloxacin loaded niosomes using combination of Span-60 and Lipotin A, to increase the local effect of Ciprofloxacin on the bacterial infected skin. Ciprofloxacin encapsulated niosomes were formulat...