EVALUATION OF ANTIDEPRESSANT ACTIVITY OF ETHANOLIC EXTRACT MOMORDICA CHARANTIA UNRIPEN FRUIT
Journal Title: International Journal of Pharmaceutical Sciences and Drug Research - Year 2015, Vol 7, Issue 1
Abstract
The aim of the present study was to investigate the antidepressant activity of Momordica charantia in swiss albino mice. In this study ethanolic extract of unripen fruit along with seeds of this plant was investigated by using animal models like Despair Swim Test (DST) and Tail Suspension Test (TST) along with 100, 300 and 500 mg/kg (p.o.) doses and distilled water as a vehicle for 14 days of treatment and imipramine as a standard drug was administered orally on the test days. During dosing period test was carried out on 1st, 7th and 14th day of treatment. The results showed a significant decrease in immobility time of treated mice as compared to control group.
Authors and Affiliations
T. Saldanha, D. Kaspate, B. Karmarkar, K. Shah, S. Narkhede
Keywords
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