Abstract

Objective: S.grandiflora flower has been used in folk medicine of India and Nepal for the treatment of diabetes mellitus. However, no scientific evidence has been available to support its use of flower part in traditional medicine. The present study was conducted to investigate the antidiabetic activity of 70% alcoholic extract of S.grandiflora flower in alloxan induced diabetes rats. Materials and Methods: Antidiabetic activity was screened in alloxan induced diabetic rats at dose of 250 mg/kg and 500 mg/kg of the 70% alcoholic extract of S.grandiflora flower for 28 days per orally. Glibenclamide (0.5 mg/kg, p.o.) used as the standard drug was administered for 28 days. The fasting blood glucose was measured at 1st, 7th, 14th and 28th day by glucometer and biochemical parameters are serum total cholesterol, triglyceride, SGOT, SGPT and BUN were assessed by semiautoanyser using biochemical kits. At the end of 28th day, pancreases were isolated for histopathology. Results: The alcoholic extract at the dose of 250 and 500 mg/kg of S.grandiflora flower exhibited significant (p<0.01) antidiabetic activity compared to diabetic control. Further the extract of both doses showed significant (p<0.01) reduction of serum total cholesterol, triglyceride, SGOT, SGPT and BUN in diabetic rats compared to diabetic control. Conclusion: The study indicates that 70% alcoholic extract of S. grandiflora flower possesses an antidiabetic activity in dose dependent manner in diabetic rats.

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