Evaluation of antidiabetic activity of alcoholic extract of Sesbania grandiflora flower in alloxan induced diabetic rats
Journal Title: Asian Journal of Pharmacy and Pharmacology - Year 2015, Vol 1, Issue 1
Abstract
Objective: S.grandiflora flower has been used in folk medicine of India and Nepal for the treatment of diabetes mellitus. However, no scientific evidence has been available to support its use of flower part in traditional medicine. The present study was conducted to investigate the antidiabetic activity of 70% alcoholic extract of S.grandiflora flower in alloxan induced diabetes rats. Materials and Methods: Antidiabetic activity was screened in alloxan induced diabetic rats at dose of 250 mg/kg and 500 mg/kg of the 70% alcoholic extract of S.grandiflora flower for 28 days per orally. Glibenclamide (0.5 mg/kg, p.o.) used as the standard drug was administered for 28 days. The fasting blood glucose was measured at 1st, 7th, 14th and 28th day by glucometer and biochemical parameters are serum total cholesterol, triglyceride, SGOT, SGPT and BUN were assessed by semiautoanyser using biochemical kits. At the end of 28th day, pancreases were isolated for histopathology. Results: The alcoholic extract at the dose of 250 and 500 mg/kg of S.grandiflora flower exhibited significant (p<0.01) antidiabetic activity compared to diabetic control. Further the extract of both doses showed significant (p<0.01) reduction of serum total cholesterol, triglyceride, SGOT, SGPT and BUN in diabetic rats compared to diabetic control. Conclusion: The study indicates that 70% alcoholic extract of S. grandiflora flower possesses an antidiabetic activity in dose dependent manner in diabetic rats.
Herbal formulation of Cocos nucifera L. for treatment of eczematic infections: An in vitro study
Objective: In the present study we describe in-vitro efficacy of Cocos nucifera L. (family Arecaceae) husk fiber extract ointment for growth inhibition of four microbes (Candida albicans, Aspergillus fumigatus, Staphyloc...
Analgesic and anti-nociceptive activity of hydroethanolic extract of Capparis decidua (Forssk.) Edgew.
Objectives: To study the analgesic and anti-nociceptive activity of hydro-ethanolic stem extract of Capparis decidua (Forssk.) Edgew. Materials and methods: Wistar rats and Swiss albino mice were selected for study of an...
Current treatment for Rheumatoid Arthritis
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Preclinical evaluation of Alpinia galanga rhizomes for wound healing activity with reducing oxidative status
Objective: The wound healing is a complex dynamic process consists of four integrated and overlapping phases: hemostasis, inflammation, proliferation and tissue remodeling. These phases and their biophysiological functio...
Ameliorative effect of Alpinia galanga rhizomes on Freund's complete adjuvant induced arthritis in mice
Arthritis is a inflammatory autoimmune disorder resulting in joint that is marked by swelling, pain, functional destruction and muscle wasting. The objective of present study was to evaluate rhizomes of Alpinia galanga f...