Evaluation of Antidiabetic Activity of Triumfetta Pilosa Roth in Streptozotocin-Induced Diabetic Rats
Journal Title: International Journal of Pharmaceutical Sciences and Research (IJPSR) - Year 2011, Vol 2, Issue 3
Abstract
The present study aims to evaluate medicinal use of Triumfetta pilosa for the treatment of diabetes. Antidiabetic activity of ethanolic extract of Triumfetta Pilosa Roth was evaluated for in-vivo hypoglycemic activity using Streptozotocin induced diabetic rats. Different biochemical parameters were used to determine the blood glucose levels using streptozotocin induced diabetes and analyzed it effect in kidneys after 21 days treatment. Ethanol extract had shown significant protection and lowered the blood glucose levels when compared to normal in glucose tolerance test. In kidney the changes caused after induction of diabetes showed degeneration’s in proximal tubular epithelial cells in the cortex of kidneys, hemorrhage in the interstitial area and periglomerular lympolytic infiltration and hyalinization of the arterioles which was reduced after feeding with Triumfetta Pilosa .Ethanolic extract of Triumfetta Pilosa prevented alteration in kidney pathology.
Authors and Affiliations
D Ramakrishna , G Vidyasagar , K Pavan Kumar , Madhusudhana Reddy I, VSS S Gupta Atyam
Keywords
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