EVALUATION OF ANTIDIABETIC AND ANTIHYPERLIPIDEMIC EFFECT OF VERNONIA DIVERGENS IN STREPTOZOTOCIN-INDUCED DIABETIC RATS
Journal Title: Asian Journal of Pharamceutical and Clinical Research - Year 2019, Vol 12, Issue 5
Abstract
Objective: The current investigation for antidiabetic activity of the plant Vernonia divergens (DC.) Edgew. has not been reported till date. However, to enlighten the folkloric claim of the plant, the study was carried out on various animal models such as albino mice, albino rabbits, Wistar rats, rabbits, hamsters, dogs, and monkeys. Methods: The whole plant of V. divergens was studied on various animal models. Screening methods generally have been carried out on rodents and non-rodents, respectively. Various biochemical and hematological parameters such as serum glucose, plasma insulin, lipid profile and activities of liver enzymes, red blood cells, white blood cells, hemoglobin, and differential counts were measured to assess the antihyperglycemic and antihyperlipidemic activities as well as safety profile of the extract. Results: Among all experimental extracts of V. divergens, it was found that the aqueous and methanolic extracts had maximum control of blood glucose in diabetic Wistar rats. While comparing with normoglycemic animals, it was observed that reduction of blood sugar level and increase in plasma insulin level are maximum with test extract. Among the study, the effects of the methanolic extract of V. divergens (MEVD) and aqueous extract of V. divergens (AEVD) were done through oral route in both the models, i.e., normoglycemic and hyperglycemic animal models. The safety profile was evaluated by toxicological evaluation and observed that, even at a higher dose level of 3000 mg/kg body weight, the MEVD and AEVD were safe and retain normal physiological and behavioral effect. The whole protein, whole cholesterol, aspartate aminotransferase, alanine aminotransferase, and alkaline phosphatase enzyme activity of streptozotocin-administered rats showed significantly higher than normal rats, and the test extract-treated rats significantly reduced the elevated levels. Conclusion: It is concluded that the MEVD and AEVD (DC.) Edgew. might be beneficial in effectively reducing the blood glucose concentration and managing the various complications of diabetes. However, in comparison between both the extracts, the methanol extract was found to be significantly more potent than that of the A.E. in all aspects.
Authors and Affiliations
LAXMIDHAR MAHARANA , MANOJ KUMAR SETHI , RUDRA NARAYAN DASH , SNIGDHA PATTNAIK
Keywords
Related Articles
- EP ID EP604725
- DOI -
- Views 138
- Downloads 0
FLUORESCENCE ANALYSIS, PHYTOCHEMICAL, AND ANTIOXIDANT ACTIVITIES IN LEAVES AND STEM OF EMBELIA RIBES BURM. F
Objective: The objective of the present study is to carry out fluorescence analysis, phytochemical, and antioxidant activities using different solvent extract in leaves and stem of Embelia ribes. Methods: In the present...
THE PROTECTIVE EFFECTS OF ECHINOPS HETEROPHYLLUS AQUEOUS EXTRACT AGAINST METHOTREXATE-INDUCED HEPATOTOXICITY IN RABBITS
Objective: The aim of this study was to investigate antioxidant and hepatoprotective properties of Iraqi Echinops heterophyllus aqueous crude extract and its flavonoid fraction against methotrexate (MTX)-induced hepatoto...
ACTIVITY OF INDIAN TOPICAL SKIN PHARMACEUTICALS AGAINST SOME FUNGAL PATHOGENS
 Objective: The aim was to assess the in vitro antifungal activity of some locally available pharmaceutical preparations used to cure skin diseases. Mostcommonly used preparations were evaluated for dermatophytic and no...
THE COMBINED EFFECT OF DEXAMETHASONE AND BACILLUS CALMETTE–GUÉRIN ON THE NEUROBEHAVIORAL ASPECT IN MALE MICE (MUS MUSCULUS)
Objective: Our study aims to evaluate the combined effect of Bacille Calmette–Guérin (BCG) and dexamethasone (DEX) on male mice undergoing behavioral testing (forced swimming test, elevated plus maze, tail suspension tes...
RECENT REPORTS ON PYRAZOLE-BASED BIOACTIVE COMPOUNDS AS CANDIDATE FOR ANTICANCER AGENTS
  Pyrazole is a five-membered heterocyclic compound containing two nitrogen atoms. Due to its biological significance, design of novel pyrazole derivatives has become an interesting research area. We report the current...