Evaluation of antidiabetic, anti-inflammatory and LDL oxidation inhibitory potential of Alpinia galanga and Alpinia calcarata -An in vitro study
Journal Title: Trends in Phytochemical Research - Year 2017, Vol 1, Issue 4
Abstract
Alpinia galanga and Alpinia calcarata are two important aromatic medicinal plants belong to the family Zingiberaceae. In the present study, dried rhizomes of A. galanga and A. calcarata were extracted with water and then fractionated with different solvents. Among the various solvent fractions, ethyl acetate (EA) fraction of both the plants showed high polyphenolic content with better antioxidant activity. This polyphenol rich EA fraction is also screened for its antidiabetic and anti-inflammatory potential using in vitro assays. Results showed that EA fractions of these two plants had significant antihyperglycemic activity by inhibiting carbohydrate digesting enzymes (α-amylase and α-glucosidase) and by inhibiting glycation reaction. Inhibitory potential of EA fractions of both the plant against protein denaturation and xanthine oxidase validates its anti-inflammatory potential. Moreover, EA fractions also exhibited significant LDL oxidation inhibition .The observed antidiabetic and anti-inflammatory properties of A. galanga and A. calcarata could be due to the synergic effect of polyphenols such as gallic acid and ellagic acid as well as bioactive alkaloid, berberine.
Authors and Affiliations
Suresh Nampoothiri, Thirugnanasamy Esakkidurai, Kasi Pitchumani
Keywords
Related Articles
- EP ID EP680547
- DOI -
- Views 142
- Downloads 0
Influence of different solvent polarities on the phenolics, flavonoids and antioxidant properties of the fruit of Xylopia aethiopica (Dunal) A. Rich
The aim of the present study was to evaluate the influence of different solvents with different polarities on the antioxidant properties of the fruit of Xylopia aethiopica (Dunal) A. Rich. The phenolics and flavonoids in...
Isolation and identification of bioactives organics compounds from the bark and seeds of Santaloïdes afzelii (Connaraceae)
Santaloïdes afzelii (R.Br. ex Planch.) Schellenb (Connaraceae) is used in Africa as an analgesic, aphrodisiac and in the treatment of stomachaches, muscular pains and in medico magic rites. The present study aims to iden...
Genetic variability, D2 analysis and characters association among quantitative and qualitative traits of spearmint (Mentha spicata L.)
An investigation was carried out to assess the genetic variability, genetic divergence and association of pheno-morphic and agronomic traits along with major chemical constituents of essential oil in 41 accessions of spe...
Effect of freeze-drying and spray-drying on total phenolics content and antioxidant activity from aqueous extract of Justicia secunda leaves
This study aims to evaluate the effect of freeze-drying and spray-drying on total phenolics contents and antioxidant capacity from aqueous extract of Justicia secunda leaves. Total phenolic compounds extraction procedu...
UPLC in phytochemical analysis
Ultra Performance Liquid Chromatography (UPLC), which has been around just over one and a half decade, is an advanced liquid chromatographic technique that offers a significantly short analysis time and small amount of s...