EVALUATION OF ANTIDIARRHEAL ACTIVITY OF METHANOLIC EXTRACT OF DAEMIA EXTENSA R. BR. SEEDS
Journal Title: Journal of Drug Delivery and Therapeutics - Year 2017, Vol 7, Issue 7
Abstract
Diarrhea is one of the most general causes for thousands of deaths each year. Consequently, identification of new source of antidiarrheal drugs becomes one of the most prominent focuses in modern research. Our aim was to investigate the antidiarrheal activity of methanolic extract of Daemia extensa R. Br. (MEDE) leaves in rats. Antidiarrheal effect was evaluated by using castor oil-induced diarrhea at 200 mg/kg and 400 mg/kg body weight in rats where the extract showed considerable antidiarrheal effect by inhibiting 49.47% and 62.85% of diarrheal period at the doses of 200 and 400mg/kg, correspondingly These observed effects are comparable to that of standard drug loperamide (5mg/kg). So these results indicate that bioactive compounds are present in methanolic extract of Daemia extensa leaves including significant anti-diarrheal activity and could be accounted for pharmacological effects.
Authors and Affiliations
Praveen Sharma
Keywords
Related Articles
- EP ID EP302207
- DOI -
- Views 85
- Downloads 0
ANTIPROLIFERATIVE AND APOPTOGENIC EFFICACY OF ANTIDIABETIC DRUGS METFORMIN AND SITAGLIPTIN AGAINST MCF7 AND HEPG2 CANCER CELLS: A COMPARATIVE MOLECULAR STUDY
Lifestyle and diet-related disorder type 2 diabetes (T2D), has reached epidemic margin globally. The relationships between diabetes and cancer are complex. However, evidence supports the hypothesis that obesity raises th...
Croton sparsiflorus whole plant extract mediated biosynthesis of metallic silver nanoparticles and their antibacterial activity
In the present study, the potential of aqueous whole plant extract of Croton sparsiflorus for biosynthesis of silver nanoparticles (AgNPs) was evaluated. The formation of AgNPs was confirmed by color changes and UV- Visi...
WOMEN SPECIFIC VARIABLES IN CARDIOVASCULAR DISEASES
Over the past decade or more, the prevalence of traditional risk factors for cardiovascular diseases has been increasing in the major populous countries of the developing world, including India, with consequent increases...
FORMULATION OF PACLITAXEL LOADED NANOSTRUCTURED LIPID CARRIERS TO STUDY THE EFFECT OF CONCENTRATION OF LIQUID LIPIDS ON DRUG RELEASE
In the present study, stearic acid (SA) nanostuctured lipid carriers (NLC) with different proportions of oleic acid (OA) were successfully prepared by solvent diffusion method in an aqueous system. OA was taken in the co...
PREPARATION AND EVALUATION OF POLYMERIC NANOPARTICLES OF GLIBENCLAMIDE
Simple, reliable and reproducible method was used for the preparation of polymeric nanoparticles of Glibenclamide. The formulation was prepared by solvent evaporation method using magnetic stirrer with overnight stirring...