Evaluation of antimalarial effect of methanol root extract of Costus Lucanusianus in the treatment of malaria-infested albino mice
Journal Title: Innovations in Pharmaceuticals and Pharmacotherapy (IPP) - Year 2017, Vol 5, Issue 2
Abstract
This study is one of its kinds because there is little or no published work on the plant in question. Aim: This study was conducted to evaluate the antimalarial activity of methanol root extract of Costus lucanusianus on chloroquine-sensitive Plasmodium berghei berghei infection in mice. Method: The plant extract was screened for blood schizontocidal activity against chloroquine-sensitive Plasmodium berghei infection in the mice. The schizontocidal activity was monitored at stages of early and established infection. The methanol extract of the roots at 100, 200 and 300 mg kg-1 body weight/day dose levels were used to treat the test groups immediately after infection for the suppressive test and 72 hours post infection for the curative test while a standard antimalarial drug, Chloroquine, at a dose of 5 mg kg-1 body weight was administered as the reference drug. The control group was left untreated. The levels of parasitemia in the different groups were monitored throughout the period of study. Result: The methanol extract at 100, 200 and 300 mg kg-1 body weight/day suppressed parasitemia by 112/µl, 128/µl, 192/µl after treating for four days in the suppressive test as against 144/µl for the standard drug with significance of p<0.0001, while the level of parasitemia was reduced by 528/µl, 320/µl and 240/µl, respectively after treating for three days in the curative test as against 160±/µl for the standard drug. Conclusion: These results show that the methanol root extract of Costus lucanusianus has suppressive and also potent curative effect against P. berghei in infected mice. Thus it may therefore offer the potential for a safe, effective and affordable antimalarial drug. It therefore justifies its use by those in rural areas to treat malaria.The mechanism behind the antiplasmodial activity displayed by C. lucanusianus is yet to be demonstrated. However, some plants have been shown to elicit antiplasmodial effects either by inducing an elevation of erythrocyte oxidation or by inhibiting the synthesis of proteins.
Authors and Affiliations
Hope D. Kagbo
Keywords
Related Articles
- EP ID EP570118
- DOI -
- Views 75
- Downloads 0
Evaluation of vitamin B12 deficiency in preschool children-A pilot study in east Delhi
Anemia is an important health concern worldwide, particularly in tropical and sub-tropical countries such as in India. The objective of the present study was to determine the prevalence of vitamin B12 deficiency in pre-s...
Intravenous drug incompatibility in intensive care units - A comprehensive review
In intensive care unit, intravenous (IV) therapy is preferred over oral therapy for a faster therapeutic action. IV therapy is complex and error prone, requiring strategies to reduce the risk and complications. Once inje...
Synthesis, characterization and biological evaluation some novel schiff base and mannich base of isatin and its derivatives with benzimidazole
Isatin is a synthetically versatile substrate, where it can be used for the synthesis of a large variety of heterocyclic compounds and as a raw material for drug synthesis. In the past few decades, Isatin and its derivat...
Evaluation of cardioprotective activity of Woodfordia fruticosa flower extracts against doxorubicin induced cardiotoxicity
Woodfordia fruticosa (WF) flower extracts (Petroleum ether- PEWF; Chloroform - CHWF; Ethyl acetate- EAWF; Methanol- MEWF; Hydroalcohol - HAWF) was evaluated for the phytochemical contents using phytochemical screening an...
Formulation and development of orodispersible tablets of lornoxicam by using resinate inclusion complexes
Lornoxicam is a non-steroidal anti-inflammatory drug and it belongs to the class of oxicam. It is used for potent inhibitor of both COX-1 and COX-2. But it is a very bitter drug and insoluble in water. Aim: To mask the t...