Electrochemotherapy: An enhancement of cytotoxicity of anticancer drugs
Journal Title: Innovations in Pharmaceuticals and Pharmacotherapy (IPP) - Year 2017, Vol 5, Issue 3
Abstract
Electrochemotherapy (ECT) is a local treatment of cancer employing electric pulses to improve transmembrane transfer of cytotoxic drugs. In this article, we discuss ECT and review the steps needed to move such a treatment from initial prototypes into clinical practice. The delivery of electric pulses at the time of when a chemotherapeutic drug reaches its highest extracellular concentration considerably increases the transport through the membrane toward the intracellular targets of cytotoxicity. The two most commonly used drugs are bleomycin and cisplatin which do not freely cross the intact cell membrane and directly affect the nuclear DNA structure, adversely interfering with mitosis leading to cancer cell death. ECT, in general, can be considered as a palliative option for cancers for which standard treatments have failed or proved to be insufficient. Sarcomas, carcinomas, or melanoma tumors responded with a high percentage of complete responses when the drugs were injected intravenously or intratumorally. Due to high effectiveness of ECT in the treatment of cutaneous and subcutaneous tumors regardless of histological origin, there are now attempts to extend its use to the treatment of internal tumors. To advance the applicability of ECT to treatment of internal solid tumors, new technological developments are needed that will enable treatment of these tumors in daily clinical practice.
Authors and Affiliations
Amol Bhalchandra Deore
Keywords
Related Articles
- EP ID EP570177
- DOI -
- Views 84
- Downloads 0
Synthesis, characterization and biological evaluation some novel schiff base and mannich base of isatin and its derivatives with benzimidazole
Isatin is a synthetically versatile substrate, where it can be used for the synthesis of a large variety of heterocyclic compounds and as a raw material for drug synthesis. In the past few decades, Isatin and its derivat...
Prevalence of Pseudomonas sp. and their antibiotic sensitivity profile in burn patients
Burns are one of the most severe wounds that damage extensively the first line of defense of the body, the skin, making them easily prone to infections, thus requiring a higher level of containment to prevent infection....
Formulation and development of orodispersible tablets of lornoxicam by using resinate inclusion complexes
Lornoxicam is a non-steroidal anti-inflammatory drug and it belongs to the class of oxicam. It is used for potent inhibitor of both COX-1 and COX-2. But it is a very bitter drug and insoluble in water. Aim: To mask the t...
Neuroprotective potential of vinpocetine in epilepsy induced co-morbid depression & cognitive dysfunction in PTZ kindled rats
Epilepsy is a chronic neurological disorder and generally associated with certain psychiatric comorbidities. Among several comorbidities depressive behavior and cognitive impairment has been reported to be most debilitat...
Preterm Birth and Associated Factors among Mothers Who Gave Birth in Gondar Town Health Institutions
Background. The birth of a preterm infant has a greater risk of developmental disabilities, health, and growth problems than infants born at full term. The main aim of this study was to assess the prevalence and associat...