Synthesis, characterization and biological evaluation some novel schiff base and mannich base of isatin and its derivatives with benzimidazole
Journal Title: Innovations in Pharmaceuticals and Pharmacotherapy (IPP) - Year 2016, Vol 4, Issue 1
Abstract
Isatin is a synthetically versatile substrate, where it can be used for the synthesis of a large variety of heterocyclic compounds and as a raw material for drug synthesis. In the past few decades, Isatin and its derivatives have received much attention due to their chemotherapeutic values. This review covers updated information on the most active isatin derivatives that have been reported to show considerable pharmacological actions such as antimicrobial, anticancer, antiviral, anticonvulsant, anti-inflammatory and analgesic. From these results, ideas for future molecular modifications leading to compounds with greater favorable pharmacological properties may be derived. Isatin have been reacted with 2-(1H-benzimidazol-2-yl) aniline to form Schiff bases and the N-Mannich bases of the compounds were synthesized by reacting them with formaldehyde and several secondary amines. Investigation of antimicrobial activity of the compounds was made by the agar dilution method. The compounds are significantly active against bacteria and fungi.
Authors and Affiliations
Faruk Alam
Keywords
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