Development of non-covalent derivative of sulfasalazine with theobromine for its properties optimization
Journal Title: Innovations in Pharmaceuticals and Pharmacotherapy (IPP) - Year 2017, Vol 5, Issue 3
Abstract
To customize the biopharmaceutical parameters of a poorly soluble, disease modifying anti-rheumatic drug, sulfasalazine (SSZ) by preparing its novel non-covalent derivative (NCD). For this theobromine (TBR) was used as coformer. The novel solid form prepared by liquid assisted grinding of SSZ with TBR using catalytic amount of solvent and termed as SSZ-TBR. The ground product (SSZ-TBR) was characterized with various techniques such as differential scanning calorimetry, powder X-ray diffraction (PXRD), and spectrometric methods involving Fourier transform infrared and solid state nuclear magnetic resonance. The structure of the SSZ-TBR was determined from its PXRD pattern using Material Studio® by BIOVIA. The crystal structure also helped to understand the nature of complex and type of interactions involved in its formation and stabilization. The SSZ-TBR was further evaluated for in vitro solubility and intrinsic dissolution rate (IDR) profile. This NCD was characterized to be cocrystal of SSZ with TBR in 1:1 stoichiometry. Its crystal packing as well as nature of interactions was established by crystal structure determination. Further, the fulfillment of objective was witnessed byE increased solubility as well as IDR in comparison to the pure SSZ. The evaluation of this novel cocrystal of SSZ a poorly soluble drug with TBR exhibit potential to enhance the option of material phase in comparison to pure active pharmaceutical ingredient without disturbing its chemical structure.
Authors and Affiliations
Madhu Bala
Keywords
Related Articles
- EP ID EP570209
- DOI -
- Views 99
- Downloads 0
Prevalence of eating disorder in working and non working individual Amber Nawab1 Misbah Ansari2 Mizna Iqbal 2 Javeria Sheikh2 Nousheen Shoukat2
Background: The inspection based curriculum has been selected to feature the prevalence of eating disorder in working and nonworking individuals. Objective: The basic characteristics of a living being includes growth, mo...
Socioeconomic burden of rheumatic heart disease: An insightful look at in Indian population
Rheumatic heart disease (RHD) continues to be a major health hazard in most developing countries. RHD describes a group of short-term (acute) and long-term (chronic) heart disorders that occur as a result of acute rheuma...
Neuroprotective potential of vinpocetine in epilepsy induced co-morbid depression & cognitive dysfunction in PTZ kindled rats
Epilepsy is a chronic neurological disorder and generally associated with certain psychiatric comorbidities. Among several comorbidities depressive behavior and cognitive impairment has been reported to be most debilitat...
Study on prevalence of asthma and impact of pharmaceutical care in a clinical setting
Aim: Improvement in Asthma Control, Peak Expiratory Flow Rate (PEFR) and Asthma related Quality of Life Scores (AQLQ'S). Objectives: To document all the asthma cases admitted in the study department. To ascertain the kno...
Formulation and evaluation of novel herbal antidiabetic transdermal patch
Aim: The aim of the present study was to formulate and evaluate the Transdermal Drug Delivery System of an antidiabetic herbal drug. And to increase the efficacy and to improve the patience compliance of the herbal medic...