EVALUATION OF ANTIMICROBIAL ACTIVITY OF LITSEA GLUTINOSA
Journal Title: International Journal of Pharmaceutical Applications - Year 2011, Vol 2, Issue 1
Abstract
Litsea glutinosa is widely available throughout India. Litsea glutinosa is called as Indian Laurel in English and as Medhasaka in Sanskrit belonging to the family Lauraceae. The powdered material of Litsea glutinosa bark was extracted separately by continuous hot extraction process using soxhlet apparatus with different solvents in increasing order of polarity from Petroleum ether, Ethanol, to finally water. After extraction the extracts were subjected to Lyophilization to get dry extract & preserved in aseptic condition. The dried extracts were subjected to various phytochemical analysis to detect the presence of different phytoconstituents like alkaloids, glycosides, flavonoids, saponins, tannins, phenolic compounds. The petroleum ether extract, ethanolic extract and aqueous extracts of the Litsea glutinosa bark have the antibacterial & antifungal activity against Gram positive Staphylococcus aureus bacteria using reference standard like Procain pencillin,Gram negative like Pseudomonas aeruginosa, Salmonella typhi, E-coli bacteria using reference standard like Streptomycine sulphate. And fungal species like Aspergillus fumigatus and Candida albicans using reference standard like Griseofulvin. The bark of Litsea glutinosa, “ is one of the most popular of native drugs”, is considered to be capable of relieving pain, arousing sexual power & good for stomach are considered to be mildly astringent, include treatment of diarrohea & dysentery. Litsea glutinosa is widely used as a demulcent & as an emollient. Petroleum ether extract & Ethanolic extracts showed good activity against Pseudomonas aeruginosa. Aqueous extract & Petroleum ether extracts showed less activity as that of Ethanolic extract against Salmonella typhi. Then Ethanolic extract showed more effective activity against E-coli. Ethanolic extract had very high activity against Staphylococcus aureus. Likewise Petroleum ether extract of Litsea glutinosa effective in inhibiting the growth of Aspergillus fumigatus & Candida albicans. The phytochemical constituents of bark of Litsea glutinosa showed the effective antibacterial & antifungal activity.
Authors and Affiliations
Poornima . V. Hosamath
Keywords
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