Evaluation of Antinociceptive And Anti-Inflammatory Effect of Aqueous Seed Extract of Carica Papaya Linn In Albino Rats
Journal Title: International Journal of Medical and Health Sciences - Year 2013, Vol 2, Issue 3
Abstract
Objective: To evaluate the antinociceptive (analgesic activity) and anti-inflammatory effect of Carica Papaya (cp) linn (Aqueous seed extract) in albino rats. Material and Methods: To evaluate antinociceptive effect of Carica Papaya Aqueous seed extract (3 doses of 5mg/kg, 10mg/kg, 20mg/kg ) in albino rats by Comparing their effect with pethidine by using Radiant heat method & Contact heat method. Antiinflammatory effect of Carica Papaya Aqueous seed extract (3 doses of 5mg/kg, 10mg/kg, 20mg/kg) was assessed comparing their effect with Aspirin in albino rats by inducing acute Inflammation – by Carrageenan-induced rat paw edema method. Results: Analgesic models: Carica Papaya Aqueous seed extract treated groups with 20mg/kg has showed significant increase in reaction time at 90 minutes when compared to control group in all the two analgesic models of experiments. These findings indicate that Carica Papaya Aqueous seed extract has a promising analgesic activity in comparison with pethidine (standard). Anti-inflammatory model : Carica Papaya Aqueous seed extract treated groups with 10mg/kg and 20mg/kg has showed significant reduction in paw edema volume at 5 hours when compared to control group in acute inflammation method. These findings indicate that Carica Papaya Aqueous seed extract was exhibiting more anti-inflammatory effect in comparison with aspirin (standard). Conclusion: Carica Papya seed extract had shown significant analgesic effect with high dose and significant anti-inflammatory effect with low dose (combination with Aspirin) , moderate dose and high dose.
Authors and Affiliations
Naveen Kumar Tamma, Tadvi Naser Ashraf, L. Nagakrishna, Lakhavat Sudhakar, Sairam Challa
Keywords
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