Abstract

With the increasing side effects and decreasing effectiveness of synthetic drugs with time, trend has been moving towards the use of natural and safe drugs with less or no side effects and equal effective like synthetic drugs for curing diseases. So, in this view the present research has been done to investigate the antioxidant and first time the anticancer property of Sesbania aculeata. Plant belongs to legume family and is mainly grown for green manure. Extracts of different parts of the plant were prepared by using Soxhlet apparatus and methanol was used as choice of solvent. The antioxidant activity was checked by four different methods including DPPH free-radical scavenging, hydrogen peroxide scavenging activity, hydroxyl radical scavenging activity and iron reducing power FRAP. The anticancer activity was checked by using SRB assay against the human lung cancer cell line Hop-62. Extracts of all the tested parts of Sesbania aculeata showed excellent in vitro antioxidant activity with maximum activity of about 71-76% in seed coat extract when checked with different methods. Similarly, the seeds coat extracts exhibit anticancer potential against the tested cancer cell line while other parts showed negligible activity. The results have shown that the methanolic extracts could be the source of potential antioxidant and anticancer agents.

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