EVALUATION OF ANTIOXIDANT AND ANTIULCER ACTIVITY OF METHANOLIC EXTRACT OF GARDENIA GUMMIFERA L. IN RATS
Journal Title: Asian Journal of Pharamceutical and Clinical Research - Year 2015, Vol 8, Issue 4
Abstract
ABSTRACTObjective: The aim was to assess the effect of anti ulcer and anti oxidant activity of methanolic extract of Gardenia Gummifera (MEGG) whole plant inulcer induced rats and in-vitro anti oxidants method respectively.Methods: In the present study, the efficacy of an MEGG was evaluated against aspirin-induced ulcers in rats. G. gummifera at doses of 150 mg/kg and300 mg/kg was administered orally once daily for 6 days.Results: Results showed that extract treatments prevented ulcer area and gastric secretion in a dose-dependent manner. Administration of 2000 mg/kgextract did not show any toxicity in albino mice. In preliminary phytochemical studies identified the presence of flavonoids in the MEGG.Conclusion: According to the results, it was concluded that the whole plant of G. gummifera has significant antiulcer activity due to the presence ofpotent antioxidants like flavonoids.Keywords: Aspirin, Antiulcer, Hydrogen peroxide, Gardenia gummifera.
Authors and Affiliations
Pradeep Kumar Sabbani, Pavan Kumar Chityala, Gowrishankar Nl, Naveen Kumar, Shilpa K
Keywords
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