Evaluation of Antiulcer Activity of Abelmoschus Esculentus in Laboratory Animals.
Journal Title: International Journal of Medical Science and Innovative Research (IJMSIR) - Year 2017, Vol 2, Issue 5
Abstract
The objective of present study is to evaluate the anti ulcer activity of methanolic extract of seeds of Abelmoschus esculentus. The cause of ulceration in patients is mainly due to hypersecretion of gastric juice and pepsin. In traditional system of medicine a number of herbal preparations have been used for the treatment of peptic ulcers. The anti-ulcer activity of methanolic extract of Abelmoschus esculentus seeds was investigated by aspirin plus pylorus ligation induced gastric ulcer in rats, Indomethacin induced ulcer in rats, water immersion stress test induced ulcer in rats. In aspirin plus pylorus ligation model, Abelmoschus esculentusat doses of 200 and 400 mg/kg produced significant reduction in gastric volume, free acidity and ulcer index compared to control. In Indomethacin and water immersion stress test induced ulcer models both doses (200mg/kg & 400mg/kg) of Abelmoschus esculentusextract significantly reduced severity of ulceration. This present study indicates Abelmoschus esculentus seeds extract have potential anti ulcer activity
Authors and Affiliations
Dr. Sam Pavan Kumar G
Keywords
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