Unsolved mystery of amplifier host as a cause of Japanese Encephalitis in Acute Encephalitis Syndrome cases: Need to implement testing protocol including simultaneous testing of viral RNA, viral IgG and IgM antibodies in the amplifier host sera.
Journal Title: International Journal of Medical Science and Innovative Research (IJMSIR) - Year 2018, Vol 3, Issue 9
Abstract
Clinically diagnosed cases of Acute Encephalitis Syndrome (AES) in the paediatric age group were reported by DMO, Mayurbhanj in September, 2015 . DMET, Odisha deputed a STF Team to district Mayurbhanj to undertake detailed investigation. Out of the 6 blood samples , 3 samples (I indoor patient and 2 random samples collected from children in contact with the positive cases in village) were positive for JE IgM through Bios ELISA kit. The team suggested remedial actions on containment, preventive measures to be initiated at field level and followed up the effect of coordinated and prompt steps taken by the government. 56 serum samples of the animal hosts (pigs) were found to be negative by Japanese Encephalitis (JE) (IgM) Capture ELISA for JE infection. After initiation of vector control measures like IRS and Fogging , use of mosquito nets and JE vaccination in 2017 in the affected villages, except for only one positive case reported at RMRC, BBSR, no further case of JE has been reported till date. As the mystery of amplifier host remains unsolved, there is a need to implement simultaneous testing of viral RNA, viral IgG antibody and viral IgM antibody in the sera of suspected amplifier host.
Authors and Affiliations
Dr. Nidhi Prasad
Keywords
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