EVALUATION OF ANTIULCER ACTIVITY OF PROSOPIS JULIFLORA ETHANOL EXTRACT IN ETHANOL INDUCED GASTRIC ULCERATION IN RATS
Journal Title: Int J of Pharm Rev& Res - Year 2014, Vol 4, Issue 1
Abstract
There has been much interest in herbal medicines derived from the traditional knowledge of plant pharmacology for treatment of ulcer as there are fewer side effects. In the current study the plant Prosopis juliflora components have been explored as a potentially effective and safer antiulcer compound. A plant which is rich in Alkaloid, Flavonoids, Tannins, Anthraquinones and Quinon are responsible for inhibition of H+, K+ ATPase, inhibition of H. Pylori growth and antioxidant activity. Twenty four wistar rats were randomly allotted to four groups (6 animals per group) Group 1 was treated with water for Injection (10 ml/kg). Group 2 was treated with Ranitidine (50 mg/kg p.o dissolved in water for Injection). Groups 3 and 4 were treated with ethanol extract of Prosopis juliflora (250 and 500 mg/kg p.o. respectively). One hour after pre-treatment with test compounds, all animals of all the groups were treated with absolute ethanol at a dose volume of 1 ml/animal. Macroscopic examination was carried out with the hand lens and the presence of ulcer lesions was scored. The animals treated with Ranitidine (50 mg/kg), an ethanol extract of Prosopis juliflora (250 and 500 mg/kg) significantly reduced the ulcer score in comparison with ethanol induced ulcer control
Authors and Affiliations
Jagan Mohan Reddy P , Tejaswini DM , Ismail Shareef M, , Narasimha Murthy TP , Gopinath SM
Keywords
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