FORMULAION AND INVITRO EVALUATION OF PIOGLITAZONE HYDROGEL TABLETS
Journal Title: Int J of Pharm Rev& Res - Year 2015, Vol 5, Issue 1
Abstract
Pioglitazone is an anti-hyperglycemic agent used in Type-2 diabetes. It is highly soluble in water. It is an orally administered drug with biological half -life of 3-6 hours. Dose of this drug is 15-45mg a day used according to the severity of infection. It also showed uneven absorption in presence and absence of food (it is advisable to take the drug along with food).Till date there is no sustain release tablets of this drug is available in the market. Thus sustain release hydrogel tablets of present drug was prepared and evaluated to provide sustained release of drug from the matrices there by to maintain a desired drug concentration in plasma which is the primary objective of any therapeutic dosage form. This can also encounters the existing draw backs such as local adverse effects, uneven absorption of this drug. Patients with type-2 diabetes often use several drugs concurrently and hence suffer from harmful drug-drug interaction. To find the effect of bioavailability of pioglitazone in diabetes and non-diabetic condition and to study the anti-diabetic activity of pioglitazone with FT-IR Spectroscopic analysis was performed to study the drug-excipients from the FTIR, There is no interaction between the drug and polymer used in formulation. Dissolution studies were performed for 12 hours study in simulated intestinal fluid (pH-6.8), at the temperature of 37±0.50C at 50rpm.
Authors and Affiliations
SK. Sharief , K. Mahalakshmi , V. Uma Maheshwara Rao , B. Arun kumar , CH. Venkateshwarlu
Keywords
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