EVIDENCE BASED UPDATE ON NSAIDS: OVERVIEW
Journal Title: Int J of Pharm Rev& Res - Year 2014, Vol 4, Issue 4
Abstract
NSAIDs have a more significant effect on pain resulting from the increased peripheral sensitization that occurs during inflammation and leads nociceptors to respond to stimuli that are normally painless. The goal of this paper is to review current literature on history, mechanisms of action, efficacy, and tolerability of OTC analgesics (NSAIDS). Relatively new and potential future indications for these drugs are also discussed. Literature search was performed in January 2012 in the following electronic database: Medline, Ebsco, Pubmed, Dove Press, Bentham Publishers, and the Cochrane Library. We collected literature from 1968 to January 2012, search terms were as follows; complication, use, prevention and mechanisms of NSAIDs. This review has enlighten the pharmacological basis for the common therapeutic approaches to pain management and also elucidate the diagnosis of acute and chronic exposure of NSAIDs poisoned patients. The article briefly describe about the classification, clinical features, diagnosis, pathogenesis, fatal dose, autopsy features and management of the NSAIDs poisoning. Finally, we touch on prevention and newer therapy that might be effective in the near future.
Authors and Affiliations
Vijaya kumar S1 , Sasi kala M
Keywords
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