EVALUATION OF ANTIUROLITHIATIC ACTIVITY OF HYDRO-ALCOHOLIC AND AQUEOUS LEAF EXTRACT OF BARLERIA PRIONITIS IN ALBINO RATS
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2014, Vol 5, Issue 7
Abstract
Leaves of Barleria prionitis (Family- Acanthaceae) are used in folklore medicine for various urinary ailments such as diuresis, urethral discharge and in dysuria. The present study is to investigate the Antiurolithiatic activity of Hydro-alcoholic and aqueous leaf extract of Barleria prionitis in Albino Rats. Renal calculi were induced in rats by supplementing water with 0.75 % v/v Ethylene glycol for 28 days. Antiurolithiatic activity was then measured by estimation of biochemical Serum (Blood Urea Nitrogen, Creatinine, Uric acid) and biochemical Urinary (Oxalate, Calcium, Phosphate) parameters. Preventive regimen (PR) and Curative regimen (CR) of Barleria prionitis Hydro-alcoholic extract (Alc.E) 400 mg/kg and Aqueous extract (Aq. E) 400 mg/kg significantly (p < 0.001) lowered the increased urinary and serum parameters whereas Preventive regimen and Curative regimen of Barleria prionitis Alc. E 200 mg/kg and Aq. E 200 mg/kg were less significant (p < 0.05). The histopathological evaluations of kidney samples were in support of the obtained result. Based on the above results a conclusion can be made that the Barleria prionitis Hydro-alcoholic and aqueous leaf extracts play a role in reduction and prevention of urinary stones.
Authors and Affiliations
Mohammed Atif, Baquer Syed
Keywords
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- EP ID EP142292
- DOI 10.7897/2230-8407.0507120
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