Evaluation of Breast Lumps in Females with Assessment of Estrogen Receptor, Progesterone Receptor and HER2/NEU Status in Patients with Breast Carcinoma
Journal Title: Scholars Journal of Applied Medical Sciences - Year 2018, Vol 6, Issue 1
Abstract
Breast lump is one of the most common surgical problems in females. Diagnosis of breast lesions is routinely performed by the triple assessment. Determination of hormone receptors and human epidermal growth factor receptor 2 (HER2/neu) is important for optimal management in breast cancer patients. The aim of this study is to evaluate the pattern of breast lumps in females with assessment of expression of estrogen, progesterone receptors and Her2/neu in breast carcinoma. This study included a total of 50 patients presenting with palpable breast lesions to Northern Railway Central Hospital (NRCH), New Delhi from May 2012 to June 2015. 50 patients presenting with a palpable breast lesion were included in this study. The breast lesions were classified into benign and malignant and were analyzed in various age groups. Out of 50 patients 25 (50 %) were diagnosed to have a benign aetiology and 25 patients (50 %) were given a diagnosis of malignancy. Highest incidences of benign breast lesions in our study (44%) were in the age group of 20 – 30 yrs and malignant lesions (40%) were between the age group of 50-60 years. Estrogen receptor and progesterone receptor status and HER-2/NEU status was evaluated by immunohistochemistry or supplemented by FISH. Out of 25 IDC cases, the receptor distribution was ER+/PR+ (32%), ER+/PR- (16%), ER-/PR+ (4%), ER+/PR+Her2+ (12%), ER-/PR-Her-2- (16%) and Her2+ 20%. It is recommended to effectively use these parameters to prognosticate and treat breast cancer patients.
Authors and Affiliations
Prachi Garg, Pamelle Yadav
Keywords
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