Evaluation of Carrageenan Induced Anti-Inflammatory & Anti Pyretic Activity of Various Extracts of Bauhina Variegata Linn in Rats
Journal Title: Scholars Journal of Applied Medical Sciences - Year 2017, Vol 5, Issue 10
Abstract
Abstract: The aim of the present study was to explore the probable anti-inflammatory activity of different extracts of Bauhina Variegata Linn using Carrageenan induced inflammation in the mice. Rats were treated orally with normal saline (as control group) and Bauhina Variegata Linn (200 and 400 mg/kg), 60 min before 0.1 mL 1% carrageenan injection. Paw volume was measured before and 1, 2, and 3 h after the injection of carrageenan. The results were expressed as the Mean ±SEM and the statistical significance of differences between groups was analyzed by One Way Analysis of Variance (ANOVA) followed by Dunnett’s test. The sub plantar injection of carrageenan caused a time-dependent paw edema in the Rats. Oral administration of Bauhina Variegata Linnextract (200 and 400 mg/kg) inhibited paw swelling dose-dependently at 1, 2, and 3, h after Carrageenan injection. We can conclude from the outcome of the present work that Bauhina Variegata Linnexert an excellent anti-inflammatory effect in the mice. Keywords:Bauhina Variegata Linn, carrageenan, Subplantar, anti-inflammatory.
Authors and Affiliations
Venkata Padmavathy Velisetty Velisetty, Perumallapalli Kamala Subhashini, V. Prapanna
Keywords
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