Evaluation of cilnidipine as bronchial smooth muscle relaxant in guinea pigs
Journal Title: Medpulse International Journal of Pharmacology - Year 2017, Vol 4, Issue 1
Abstract
Background: Chloride (Cl-), being the most abundant permeable anion, plays an important role in various cellular functions. Impairment in the transport of Cl- is known to cause epilepsy, cystic fibrosis, myotonia, lysosomal storage disease, deafness, renal stones, and osteoporosis Methodology: Healthy adult guinea pigs of either sex from animal house Medical College were used for study, Pregnant and diseased guinea pigs were excluded. The body weight of these animals varied from 400 to 600 grams. Results: The mean PCD time for the control group is 60.5 sec with a standard deviation of ± 2.42 seconds. The mean PCD time for the standard group treated by oral salbutamol in the dose of 4.5mg/kg body wt. is 371 seconds with a standard deviation of ±10.41 seconds. Conclusion: The tests drugs, i.e. Cilnidipine and Amlodipine showed a significant increase in the PCD time after exposure to Acetyl choline when compared to the control group.
Authors and Affiliations
M D Sibgatullah, Satish A M, Shruthi S L
Keywords
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