EVALUATION OF CLINICAL EFFICACY OF SINGLE DOSE OF VAGINAL PESSARY SERTACONAZOLE VERSUS CLOTRIMAZOLE IN TREATMENT OF UNCOMPLICATED VAGINAL CANDIDIASIS
Journal Title: Journal of Evolution of Medical and Dental Sciences - Year 2018, Vol 7, Issue 38
Abstract
BACKGROUND Sertaconazole is a new imidazole fungicide introduced for vulvovaginal candidiasis. It has an azole group with benzothiophene that inhibits biosynthesis of ergosterol and brings about a massive leak of cytoplasm with consequent fungal cell death. The objective of this study is to evaluate clinical efficacy of single-dose vaginal pessary Sertaconazole versus Clotrimazole in uncomplicated vaginal candidiasis. MATERIALS AND METHODS Patients attending gynaecological and obstetric OPD with a clinical diagnosis of vaginal candidiasis are studied. Vaginal swabs are taken for microscopy and gram staining examination from patients. Patients in Group 1 receives single-dose vaginal pessary Sertaconazole 300 mg and subjects in Group 2 single-dose vaginal pessary Clotrimazole 500 mg. Patients are evaluated at the end of 7 days and 28 days for symptomatic relief, side effect and mycological clearance. Main Outcome Measures: Primary outcome will be clinical cure. Secondary outcome is mycological cure. Study Design- A prospective, non-randomised, controlled parallel trial. Setting- PESIMSR, a tertiary referral centre, Kuppam. RESULTS In gynaecological group, 27.3% of people in sertaconazole group and 77.3% patients in clotrimazole group had symptoms at the end of 7 days. At the end of 28 days only 15.8% in sertaconazole group had symptoms, while 55.6% patients had persisting symptoms in clotrimazole group. Positive vaginal smear was 36.4% at the end of 7 days of treatment while it was 85.7% in clotrimazole group and the proportion of positive smear in sertaconazole group at the end of 28 days was 15.8% while it was 66.7% in clotrimazole group. On gram staining at the end of 7 days 56.5% patients in sertaconazole group had no organisms on gram staining, while only 13.0% in clotrimazole had no organism on smear examination. After 28 days of treatment with 85.0% in sertaconazole group with no organism on gram staining, while only 33.3% patients in clotrimazole group became free of organisms. In obstetric group at the end of 7 days only 39.1% patients in sertaconazole group had symptoms while 66.3% patients in clotrimazole group and at the end of 28 days 4.8% in sertaconazole group had symptoms, while all patients had persisting symptoms in clotrimazole group. Positive vaginal smear was 54.5% at the end of 7 days of treatment, while it was as high as 95.5% in clotrimazole group. Similarly, the proportion of positive smear in sertaconazole group at the end of 28 days came down to 15.0%, while it was still as high as 50.0% in clotrimazole group. On gram staining 47.8% patients in sertaconazole group had no organisms, while only 9.1% in clotrimazole group had no organisms. After 28 days of treatment with 85.7% in sertaconazole group with no organism on gram staining, while only 28.6% patients in clotrimazole group became free of organisms. CONCLUSION In this study, single-dose Sertaconazole was more effective than Clotrimazole in producing symptomatic and mycological clearance in both obstetric and gynaecological group. Because Sertaconazole was given as a single dose, it has additional advantage of better compliance and less emergence of resistance.
Authors and Affiliations
Sabitha Umapathy Srinivasan, Hemalatha Reddy, Pradeep Shivaraju
Keywords
Related Articles
- EP ID EP548065
- DOI 10.14260/jemds/2018/933
- Views 49
- Downloads 0
ANAESTHETIC MANAGEMENT OF PATIENT WITH GILBERT’S SYNDROME
Gilbert’s syndrome is characterized by mild unconjugated hyperbilirubinemia without either structural liver disease or hemolytic anemia. Bilirubin is produced during the breakdown of hemoglobin and hemoprotei...
A DESCRIPTIVE STUDY ON SAMM OR NEAR-MISS CASES WITH COMPARISON TO MATERNAL MORTALITIES AND IDENTIFICATION OF THE BARRIERS IN A TERTIARY CARE HOSPITAL IN SOUTH BENGAL
BACKGROUND It is well known that SAMM cases or near-miss cases are defined as those very ill pregnant mothers who would have died, had it not been that luck and good care by her side.1 To fight the near-miss cases, promp...
NEURILEMMOMA (SCHWANNOMA) OF UPPER EYELID
PRESENTATION OF CASE A 20-year-old young man came to Eye OPD of our hospital with a complaint of painless nodule which enlarged slowly for 1 year on his left upper eyelid in outer part and in between upper orbital margin...
PATTERN OF FATAL CHEST INJURY DUE TO ROAD TRAFFIC ACCIDENTS IN BIHAR STATE
Bihar is relatively a backward state of India where deaths due to chest injuries in road traffic accidents are very common. Deaths due to chest injuries could be more preventable and treatable than head injuries...
A STUDY OF CLINICAL PROFILE, AETIOLOGY AND OUTCOME OF PATIENTS PRESENTING WITH PLEURAL EFFUSION
BACKGROUND Pleural effusion is excess fluid that accumulates in the pleural space which is always abnormal and indicates the presence of an underlying disease. Excessive amounts of such fluid can impair breathing by limi...