EVALUATION OF CLONIDINE FOR ATTENUATION OF HAEMODYNAMIC RESPONSES DURING LARYNGOSCOPY AND INTUBATION
Journal Title: Journal of Evolution of Medical and Dental Sciences - Year 2018, Vol 7, Issue 37
Abstract
BACKGROUND The commonest and most discussed side effects of laryngoscopy and endotracheal intubation are acute rise in blood pressure, tachycardia and transient arrhythmias. Clonidine, an alpha-2 adrenoreceptor agonist has been shown to attenuate the cardiovascular response during laryngoscopy and intubation by various workers. The aim of the present study was to evaluate effect of clonidine on attenuation of haemodynamic responses during laryngoscopy and intubation. MATERIALS AND METHODS This study was a prospective, double-blinded, randomised controlled trial conducted on 60 patients of both sexes within the age of 18-60 years, ASA grade I and II physical status, MPS-I or II admitted for elective abdominal surgeries under general anaesthesia. Patients were randomly divided into two groups containing 30 patients in each group, received normal saline or clonidine 3 µg/kg, 15 minutes before induction of anaesthesia. Pulse rate, blood pressure, oxygen saturation and ECG changes were recorded from baseline to 10 minutes after laryngoscopy and intubation at fixed time intervals. RESULTS Both groups were demographically similar and comparable at baseline. The pulse rates and blood pressures were increased in both groups upto 1 minute after laryngoscopy and intubation, then decreased progressively and similar to baseline in 10 minutes. Increase in pulse rates and blood pressures were found much more in Group I than Group II. It was seen that clonidine prevents rise in pulse rates and blood pressures in Group II and leads to early normalisation of haemodynamic changes. There was no noticeable change on ECG and oxygen saturation in both groups during the study period. The side effects and complications of clonidine like bradycardia and hypotension were not observed in any patient during the study period. CONCLUSION In conclusion, Clonidine is beneficial in attenuating the haemodynamic responses to laryngoscopy and intubation. So, clonidine is a useful pre-medicant for routine use.
Authors and Affiliations
Parthsarthi Prasad
Keywords
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- EP ID EP548020
- DOI 10.14260/jemds/2018/919
- Views 66
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