EVALUATION OF DICHLORVOS INHALATION ON THE LIVER HISTOLOGY AND SELECTED LIVER ENZYMES ACTIVITIES IN ADULT WISTAR RATS
Journal Title: European Journal of Pharmaceutical and Medical Research - Year 2018, Vol 5, Issue 4
Abstract
Dichlorvos is one of the cheapest insecticides use to eradicate mosquitoes in Nigeria. It forms the active ingredient of the solution called Ota piapia or Madarar piapia. It binds irreversibly with acetylcholine receptors and inhibits its activity. It is metabolized in the liver and kidney. Oral ingestion of dichlorvos was commonest cause of toxicity reported however few literatures were reported on the effect of dichlorvos inhalation on the liver. The aim of this study was to evaluate the effects of dichlorvos inhalation on the liver histology and selected liver enzymes in Adult Wistar Rats. Twenty five apparently healthy Adult Wistar Rats were randomly selected and divided into five groups. Group one was used as control the rest were used as treatments for twenty eight days. The animals were sacrificed; their blood and liver tissues were collected for enzyme assay and routine histological technique respectively. Significant increase [P ˂ 0.05] in the values of the Albumin, Alkaline Phosphatase, Aspartate Aminotransferase and Alanine Aminotransferase as well as variable degrees of apoptosis and steatosis were observed in dose dependent manner in the treatment groups. Dichlorvos inhalation damaged histo-architechture and altered enzymes activities of the liver.
Authors and Affiliations
Idris Abdu Tela
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