Evaluation of effect of ethanolic leaf extract of Ocimum sanctum in experimental models of depression
Journal Title: MedPulse -International Medical Journal - Year 2014, Vol 1, Issue 9
Abstract
Introduction: Depression affects 121 million people worldwide. It can affect a person’s ability to work, form relationships and destroy their quality of life. Various drugs are available for the treatment of depression. Approximately two-thirds of the depressed patients respond to the currently available treatments but the magnitude of improvement is still disappointing. Since the depressive disorders are having a huge impact on our lives, it is worth evaluating the alternative forms of medicines which can be used for its treatment. So in this study, an effort was made to investigate the antidepressant effect of ethanolic extract of leaves of Ocimum Sanctum. Aims and Objectives: To evaluate the anti depressant activity of Ocimum Sanctum in albino mice. Material and Method: Swiss albino mice weighing 20 to 40gms of either sex were divided into 3 treatment groups, each group containing 6 animals and orally administered with 1% Gum acacia (control), Ocimum Sanctum 4mg/kg and 8mg/kg (test drug). A total of 36 animals were used. The duration of immobility was observed for 6minutes in Tail suspension test and Forced swimming test on a separate set of animals on 1st day, 8th day and 15th day. Results: The data was analyzed for statistical significance by using unpaired t test. The ethanolic extract of leaves of O. Sanctum in the above mentioned doses significantly reduced the immobility time (p < 0.05) in both Forced Swimming test model and Tail Suspension test models compared to control. Conclusion: The alcoholic extract of leaves of Ocimum Sanctum has significant antidepressant activity in acute animal models of depression.
Authors and Affiliations
Manu G, Hema N G, Parashivamurthy B M, Kishore M S
Keywords
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