Evaluation of Efficacy of Glycyrrhiza Glabra in the Management of Oral Submucous Fibrosis - A Preliminary Study.
Journal Title: International Journal of Medical Science And Advanced Clinical Research (IJMACR) - Year 2019, Vol 2, Issue 3
Abstract
Background: Oral submucous fibrosis is a chronic, insidious, progressive disease of the oral cavity strongly associated with areca nut chewing habit. Till date no conclusive management protocol is stand still in Oral submucous fibrosis, but there is always a constant research to explore pathogenesis and management. Hence attempt was made to evalaute the efficacy of glycyrrhiza glabra in the management. Objectives: Efficacy of glycyrrhiza glabra was scientifically evaluated by estimating serum antioxidant activity status and malondialdehyde levels before and after treatment. To evaluate the improvement in clinical parameters after treatment with glycyrrhiza glabra. Methods: Twenty oral submucous fibrosis patients were included in the study. All the patients had taken two 500mg glycyrrhiza glabra capsules thrice a day for three months. Serum antioxidant activity status and malondialdehyde was estimated in patients before and after therapy. Statistical analysis was done using ANOVA, paired‘t’ test and unpaired‘t’ test. Results: Improvement in burning sensation, mouth opening and tongue protrusion were statistically highly significant (p<0.001). Serum antioxidant activity status was significantly improved after therapy and malondialdehyde level was reduced after therapy. Conclusion: Glycyrrhiza glabra proved to be relatively safe, noninvasive, economical and efficatious treatment with improvement in signs and symptoms thereby enhances the patients compliances. Improvement in serum antioxidant activity status and malondialdehyde level intimates the role of oxidative stress in the pathogenesis of oral submucous fibrosis as well determines the antioxidant properties of Glycyrrhiza glabra.
Authors and Affiliations
Dr. Shakunthala G. K.
Keywords
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