Evaluation of Efficacy of Polyherbal Preparation in Prevention of Target Organ Damage and Intercurrent Infections In Experimentally Induced Diabetes Mellitus In Rats
Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2018, Vol 17, Issue 9
Abstract
Aims and objectives: 1 To evaluate the antidiabetic effect of polyherbal extract in comparison with Gliclazide 2 To evaluate the effect of polyherbal extract on serum creartinine, CRP levels and WBC counts in comparison with standard drug Gliclazide in alloxan induced diabetic Rats Materials and method: Rats were randomly divided into 5 groups, each comprising 6 rats. Group 1 - Normal control distilled water, Group 2 – standard drug gliclazide 25mg/kg, Group 3 – Polyherbal extract (T1)– 300mg/kg, group 4 – Polyherbal extract (T2)– 400mg/kg, Group 5 – Polyherbal extract (T3)– 500mg/kg was administered orally for 45 days. The fasting blood glucose, HbA1c values, S.Creatinine, CRP levels and WBC counts were estimated in both normal and alloxan induced diabetic rats. Results: The percentage reduction in FBS after 45days of treatment in T1, T2, T3 and standard groups is 31.9%, 34.4%, 50.7% and 61.03% respectively, and difference between groups is statistically significant, P value <0.0001***. Regarding HbA1c levels, the percentage reduction in T1, T2, T3 & standard groups is 33.3%(P 0.0006***), 40.1%(P<0.0001***), 43.6%(P<0.0001***) & 45%(P<0.0001***) respectively, there is significant statistical difference between different groups before and after treatment. The percentage reduction in S. Creatinine values in T1, T2, T3 and standard groups is 41.5%, 57.4%, 68.32% & 69.5% respectively with statistically significant difference between study groups, P value <0.0001.*** Similarly in case of WBC counts, the percentage reduction in T1, T2, T3 & standard groups is 25.24%, 33.27%,37.83% & 39.17% respectively during the study period, and there is statistically significant difference between different study groups with P value 0.0007.*** With regard to serum CRP levels, the percentage reduction in T1, T2, T3 & standard groups is 42.7%(P 0.0015**), 48.6%(P 0.0003***), 54.1%(P<0.0001***) and 53.1%(P<0.0001***) respectively with statistical significant difference in each group before and after treatment. Conclusion: The polyherbal extract showed excellent antidiabetic potential and its effect is comparable with Gliclazide in alloxan induced diabetic rats. Extract also showed significant reduction in S.Creatinine, CRP and WBC counts in diabetic rats after treatment.
Authors and Affiliations
Dr. K. Jayaprakash, Dr. Mahammad Juber . S
Keywords
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- EP ID EP381969
- DOI 10.9790/0853-1709042567.
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