A Study of Association between Lipid Profile and Thyroid Hormones in Pregnancy
Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2018, Vol 17, Issue 9
Abstract
Background: To study the association between lipid profile and thyroid hormones in early pregnancy Aims:To investigate lipid profiles and thyroid hormones, US -TSH , FT4, FT3 during early pregnancy. To find out the association between thyroid dysfunction and serum lipid levels during early pregnancy. Materials and methods: This prospective observational study was conducted at the Department of Biochemistry in collaboration with the Department of Obstetrics and Gynaecology, Jawaharlal Nehru Institute of Medical Sciences, Imphal during the period of July 2015 to January 2016. A total of four hundred and ninety seven pregnant women within the first twelve weeks of gestation were the study subject. Patients documented with history of hypothyroidism, thyrotoxicosis, Hypertenship pregnant women patients suffering from other medical problems , under treatments were excluded. Estimation of lipid profile were done by enzymatic colorimetric test. Estimation of ultrasensitive TSH (U-TSH) ELISA, free T3 Micro well ELISA, Free T4 Micro well ELISA – Enzyme immune assay – qualitative determination of Free T3, T4 hormone concentration of human serum were done. Results:The mean of thyroid parameters free T3, Free T4 Sensitive, (U-TSH) Elisa were, 27,71 (6.170)ng/ml, 1.82 (2.46)ng/dl, 2.93 (4.21)µIU/mL respectively. Lipid profile parameters, total cholesterol and triglyceride 209.9 (28.67)mg/dL and 189.9 (36.85)mg/dl respectively. The total cholesterol, triglyceride and VLDL values are elevated among the subclinically hypothyroid pregnant women, when compared to healthy pregnant women.It has been observed that positive correlation is seen between TSH and Triglycerides which is statistically significant (p-value 0.000). The significant correlation was also seen with cholesterol and with LDL in subclinical Hypothyroid pregnant women.Conclusion: Correlation of Lipid and Thyroid profile, Screening for Dislipidemia and Thyroid Dysfuntion in Early Pregnancy is essential to prevent Maternal and foetal pregnancy complications and outcome.
Authors and Affiliations
Dr. Rajkumari Vidyabati Devi, Dr Sujeeta Oinam, Dr. R. K. Bishwalata, Dr. Ng. Indrakumar Singh, Prof T. Rajen Singh
Keywords
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- EP ID EP381859
- DOI 10.9790/0853-1709015560.
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